Innate Immunity in Heart, Lung and Blood Disease
Programs for Genomic Applications
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European-American Asthma 13:36 Tuesday, August 12, 2003 5
SNP = IIPGA_IL18R1_14775
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |A |G | Total
---------+--------+--------+
Control | 478 | 512 | 990
| 24.41 | 26.15 | 50.56
---------+--------+--------+
Case | 461 | 507 | 968
| 23.54 | 25.89 | 49.44
---------+--------+--------+
Total 939 1019 1958
47.96 52.04 100.00
Frequency Missing = 118
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.0851 0.7705
Likelihood Ratio Chi-Square 1 0.0851 0.7705
Continuity Adj. Chi-Square 1 0.0608 0.8053
Mantel-Haenszel Chi-Square 1 0.0851 0.7705
Phi Coefficient 0.0066
Contingency Coefficient 0.0066
Cramer's V 0.0066
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 478
Left-sided Pr <= F 0.6319
Right-sided Pr >= F 0.4026
Table Probability (P) 0.0346
Two-sided Pr <= P 0.7861
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.0268 0.8599 1.2260
Cohort (Col1 Risk) 1.0138 0.9244 1.1119
Cohort (Col2 Risk) 0.9874 0.9069 1.0751
Effective Sample Size = 1958
Frequency Missing = 118
European-American Asthma 13:36 Tuesday, August 12, 2003 6
SNP = IIPGA_IL18R1_14775
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |AA |GA |GG | Total
---------+--------+--------+--------+
Control | 118 | 242 | 135 | 495
| 12.05 | 24.72 | 13.79 | 50.56
---------+--------+--------+--------+
Case | 111 | 239 | 134 | 484
| 11.34 | 24.41 | 13.69 | 49.44
---------+--------+--------+--------+
Total 229 481 269 979
23.39 49.13 27.48 100.00
Frequency Missing = 59
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 0.1128 0.9452
Likelihood Ratio Chi-Square 2 0.1128 0.9451
Mantel-Haenszel Chi-Square 1 0.0837 0.7723
Phi Coefficient 0.0107
Contingency Coefficient 0.0107
Cramer's V 0.0107
Pearson Chi-Square Test
----------------------------------
Chi-Square 0.1128
DF 2
Asymptotic Pr > ChiSq 0.9452
Exact Pr >= ChiSq 0.9467
Effective Sample Size = 979
Frequency Missing = 59
European-American Asthma 13:36 Tuesday, August 12, 2003 7
SNP = IIPGA_IL18R1_24808
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |C |T | Total
---------+--------+--------+
Control | 716 | 272 | 988
| 36.02 | 13.68 | 49.70
---------+--------+--------+
Case | 695 | 305 | 1000
| 34.96 | 15.34 | 50.30
---------+--------+--------+
Total 1411 577 1988
70.98 29.02 100.00
Frequency Missing = 88
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 2.1275 0.1447
Likelihood Ratio Chi-Square 1 2.1285 0.1446
Continuity Adj. Chi-Square 1 1.9858 0.1588
Mantel-Haenszel Chi-Square 1 2.1265 0.1448
Phi Coefficient 0.0327
Contingency Coefficient 0.0327
Cramer's V 0.0327
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 716
Left-sided Pr <= F 0.9343
Right-sided Pr >= F 0.0794
Table Probability (P) 0.0136
Two-sided Pr <= P 0.1519
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.1552 0.9516 1.4024
Cohort (Col1 Risk) 1.0427 0.9857 1.1031
Cohort (Col2 Risk) 0.9026 0.7864 1.0360
Effective Sample Size = 1988
Frequency Missing = 88
European-American Asthma 13:36 Tuesday, August 12, 2003 8
SNP = IIPGA_IL18R1_24808
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |CC |CT |TT | Total
---------+--------+--------+--------+
Control | 255 | 206 | 33 | 494
| 25.65 | 20.72 | 3.32 | 49.70
---------+--------+--------+--------+
Case | 247 | 201 | 52 | 500
| 24.85 | 20.22 | 5.23 | 50.30
---------+--------+--------+--------+
Total 502 407 85 994
50.50 40.95 8.55 100.00
Frequency Missing = 44
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 4.3999 0.1108
Likelihood Ratio Chi-Square 2 4.4359 0.1088
Mantel-Haenszel Chi-Square 1 2.1123 0.1461
Phi Coefficient 0.0665
Contingency Coefficient 0.0664
Cramer's V 0.0665
Pearson Chi-Square Test
----------------------------------
Chi-Square 4.3999
DF 2
Asymptotic Pr > ChiSq 0.1108
Exact Pr >= ChiSq 0.1130
Effective Sample Size = 994
Frequency Missing = 44
European-American Asthma 13:36 Tuesday, August 12, 2003 9
SNP = IIPGA_IL18R1_26671
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |A |C | Total
---------+--------+--------+
Control | 156 | 806 | 962
| 8.19 | 42.33 | 50.53
---------+--------+--------+
Case | 158 | 784 | 942
| 8.30 | 41.18 | 49.47
---------+--------+--------+
Total 314 1590 1904
16.49 83.51 100.00
Frequency Missing = 172
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.1071 0.7435
Likelihood Ratio Chi-Square 1 0.1071 0.7435
Continuity Adj. Chi-Square 1 0.0705 0.7907
Mantel-Haenszel Chi-Square 1 0.1070 0.7436
Phi Coefficient -0.0075
Contingency Coefficient 0.0075
Cramer's V -0.0075
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 156
Left-sided Pr <= F 0.3953
Right-sided Pr >= F 0.6514
Table Probability (P) 0.0467
Two-sided Pr <= P 0.7577
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 0.9604 0.7539 1.2234
Cohort (Col1 Risk) 0.9668 0.7899 1.1834
Cohort (Col2 Risk) 1.0067 0.9673 1.0477
Effective Sample Size = 1904
Frequency Missing = 172
European-American Asthma 13:36 Tuesday, August 12, 2003 10
SNP = IIPGA_IL18R1_26671
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |AA |CA |CC | Total
---------+--------+--------+--------+
Control | 19 | 118 | 344 | 481
| 2.00 | 12.39 | 36.13 | 50.53
---------+--------+--------+--------+
Case | 23 | 112 | 336 | 471
| 2.42 | 11.76 | 35.29 | 49.47
---------+--------+--------+--------+
Total 42 230 680 952
4.41 24.16 71.43 100.00
Frequency Missing = 86
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 0.5266 0.7685
Likelihood Ratio Chi-Square 2 0.5271 0.7683
Mantel-Haenszel Chi-Square 1 0.0953 0.7576
Phi Coefficient 0.0235
Contingency Coefficient 0.0235
Cramer's V 0.0235
Pearson Chi-Square Test
----------------------------------
Chi-Square 0.5266
DF 2
Asymptotic Pr > ChiSq 0.7685
Exact Pr >= ChiSq 0.7719
Effective Sample Size = 952
Frequency Missing = 86
European-American Asthma 13:36 Tuesday, August 12, 2003 11
SNP = IIPGA_IL18R1_942
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |A |G | Total
---------+--------+--------+
Control | 610 | 360 | 970
| 31.19 | 18.40 | 49.59
---------+--------+--------+
Case | 596 | 390 | 986
| 30.47 | 19.94 | 50.41
---------+--------+--------+
Total 1206 750 1956
61.66 38.34 100.00
Frequency Missing = 120
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 1.2317 0.2671
Likelihood Ratio Chi-Square 1 1.2320 0.2670
Continuity Adj. Chi-Square 1 1.1307 0.2876
Mantel-Haenszel Chi-Square 1 1.2311 0.2672
Phi Coefficient 0.0251
Contingency Coefficient 0.0251
Cramer's V 0.0251
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 610
Left-sided Pr <= F 0.8762
Right-sided Pr >= F 0.1438
Table Probability (P) 0.0200
Two-sided Pr <= P 0.2848
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.1088 0.9239 1.3306
Cohort (Col1 Risk) 1.0404 0.9701 1.1157
Cohort (Col2 Risk) 0.9383 0.8384 1.0501
Effective Sample Size = 1956
Frequency Missing = 120
European-American Asthma 13:36 Tuesday, August 12, 2003 12
SNP = IIPGA_IL18R1_942
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |AA |GA |GG | Total
---------+--------+--------+--------+
Control | 186 | 238 | 61 | 485
| 19.02 | 24.34 | 6.24 | 49.59
---------+--------+--------+--------+
Case | 182 | 232 | 79 | 493
| 18.61 | 23.72 | 8.08 | 50.41
---------+--------+--------+--------+
Total 368 470 140 978
37.63 48.06 14.31 100.00
Frequency Missing = 60
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 2.3691 0.3059
Likelihood Ratio Chi-Square 2 2.3753 0.3049
Mantel-Haenszel Chi-Square 1 1.2510 0.2634
Phi Coefficient 0.0492
Contingency Coefficient 0.0492
Cramer's V 0.0492
Pearson Chi-Square Test
----------------------------------
Chi-Square 2.3691
DF 2
Asymptotic Pr > ChiSq 0.3059
Exact Pr >= ChiSq 0.3101
Effective Sample Size = 978
Frequency Missing = 60
European-American Asthma 09:28 Wednesday, August 13, 2003 5
SNP = IIPGA_IL18R1_14775
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |A |G | Total
---------+--------+--------+
Control | 478 | 512 | 990
| 24.41 | 26.15 | 50.56
---------+--------+--------+
Case | 461 | 507 | 968
| 23.54 | 25.89 | 49.44
---------+--------+--------+
Total 939 1019 1958
47.96 52.04 100.00
Frequency Missing = 118
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.0851 0.7705
Likelihood Ratio Chi-Square 1 0.0851 0.7705
Continuity Adj. Chi-Square 1 0.0608 0.8053
Mantel-Haenszel Chi-Square 1 0.0851 0.7705
Phi Coefficient 0.0066
Contingency Coefficient 0.0066
Cramer's V 0.0066
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 478
Left-sided Pr <= F 0.6319
Right-sided Pr >= F 0.4026
Table Probability (P) 0.0346
Two-sided Pr <= P 0.7861
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.0268 0.8599 1.2260
Cohort (Col1 Risk) 1.0138 0.9244 1.1119
Cohort (Col2 Risk) 0.9874 0.9069 1.0751
Effective Sample Size = 1958
Frequency Missing = 118
European-American Asthma 09:28 Wednesday, August 13, 2003 6
SNP = IIPGA_IL18R1_14775
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |AA |GA |GG | Total
---------+--------+--------+--------+
Control | 118 | 242 | 135 | 495
| 12.05 | 24.72 | 13.79 | 50.56
---------+--------+--------+--------+
Case | 111 | 239 | 134 | 484
| 11.34 | 24.41 | 13.69 | 49.44
---------+--------+--------+--------+
Total 229 481 269 979
23.39 49.13 27.48 100.00
Frequency Missing = 59
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 0.1128 0.9452
Likelihood Ratio Chi-Square 2 0.1128 0.9451
Mantel-Haenszel Chi-Square 1 0.0837 0.7723
Phi Coefficient 0.0107
Contingency Coefficient 0.0107
Cramer's V 0.0107
Pearson Chi-Square Test
----------------------------------
Chi-Square 0.1128
DF 2
Asymptotic Pr > ChiSq 0.9452
Exact Pr >= ChiSq 0.9467
Effective Sample Size = 979
Frequency Missing = 59
European-American Asthma 09:28 Wednesday, August 13, 2003 7
SNP = IIPGA_IL18R1_24808
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |C |T | Total
---------+--------+--------+
Control | 716 | 272 | 988
| 36.02 | 13.68 | 49.70
---------+--------+--------+
Case | 695 | 305 | 1000
| 34.96 | 15.34 | 50.30
---------+--------+--------+
Total 1411 577 1988
70.98 29.02 100.00
Frequency Missing = 88
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 2.1275 0.1447
Likelihood Ratio Chi-Square 1 2.1285 0.1446
Continuity Adj. Chi-Square 1 1.9858 0.1588
Mantel-Haenszel Chi-Square 1 2.1265 0.1448
Phi Coefficient 0.0327
Contingency Coefficient 0.0327
Cramer's V 0.0327
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 716
Left-sided Pr <= F 0.9343
Right-sided Pr >= F 0.0794
Table Probability (P) 0.0136
Two-sided Pr <= P 0.1519
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.1552 0.9516 1.4024
Cohort (Col1 Risk) 1.0427 0.9857 1.1031
Cohort (Col2 Risk) 0.9026 0.7864 1.0360
Effective Sample Size = 1988
Frequency Missing = 88
European-American Asthma 09:28 Wednesday, August 13, 2003 8
SNP = IIPGA_IL18R1_24808
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |CC |CT |TT | Total
---------+--------+--------+--------+
Control | 255 | 206 | 33 | 494
| 25.65 | 20.72 | 3.32 | 49.70
---------+--------+--------+--------+
Case | 247 | 201 | 52 | 500
| 24.85 | 20.22 | 5.23 | 50.30
---------+--------+--------+--------+
Total 502 407 85 994
50.50 40.95 8.55 100.00
Frequency Missing = 44
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 4.3999 0.1108
Likelihood Ratio Chi-Square 2 4.4359 0.1088
Mantel-Haenszel Chi-Square 1 2.1123 0.1461
Phi Coefficient 0.0665
Contingency Coefficient 0.0664
Cramer's V 0.0665
Pearson Chi-Square Test
----------------------------------
Chi-Square 4.3999
DF 2
Asymptotic Pr > ChiSq 0.1108
Exact Pr >= ChiSq 0.1130
Effective Sample Size = 994
Frequency Missing = 44
European-American Asthma 09:28 Wednesday, August 13, 2003 9
SNP = IIPGA_IL18R1_26671
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |A |C | Total
---------+--------+--------+
Control | 156 | 806 | 962
| 8.19 | 42.33 | 50.53
---------+--------+--------+
Case | 158 | 784 | 942
| 8.30 | 41.18 | 49.47
---------+--------+--------+
Total 314 1590 1904
16.49 83.51 100.00
Frequency Missing = 172
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.1071 0.7435
Likelihood Ratio Chi-Square 1 0.1071 0.7435
Continuity Adj. Chi-Square 1 0.0705 0.7907
Mantel-Haenszel Chi-Square 1 0.1070 0.7436
Phi Coefficient -0.0075
Contingency Coefficient 0.0075
Cramer's V -0.0075
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 156
Left-sided Pr <= F 0.3953
Right-sided Pr >= F 0.6514
Table Probability (P) 0.0467
Two-sided Pr <= P 0.7577
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 0.9604 0.7539 1.2234
Cohort (Col1 Risk) 0.9668 0.7899 1.1834
Cohort (Col2 Risk) 1.0067 0.9673 1.0477
Effective Sample Size = 1904
Frequency Missing = 172
European-American Asthma 09:28 Wednesday, August 13, 2003 10
SNP = IIPGA_IL18R1_26671
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |AA |CA |CC | Total
---------+--------+--------+--------+
Control | 19 | 118 | 344 | 481
| 2.00 | 12.39 | 36.13 | 50.53
---------+--------+--------+--------+
Case | 23 | 112 | 336 | 471
| 2.42 | 11.76 | 35.29 | 49.47
---------+--------+--------+--------+
Total 42 230 680 952
4.41 24.16 71.43 100.00
Frequency Missing = 86
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 0.5266 0.7685
Likelihood Ratio Chi-Square 2 0.5271 0.7683
Mantel-Haenszel Chi-Square 1 0.0953 0.7576
Phi Coefficient 0.0235
Contingency Coefficient 0.0235
Cramer's V 0.0235
Pearson Chi-Square Test
----------------------------------
Chi-Square 0.5266
DF 2
Asymptotic Pr > ChiSq 0.7685
Exact Pr >= ChiSq 0.7719
Effective Sample Size = 952
Frequency Missing = 86
European-American Asthma 09:28 Wednesday, August 13, 2003 11
SNP = IIPGA_IL18R1_942
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |A |G | Total
---------+--------+--------+
Control | 610 | 360 | 970
| 31.19 | 18.40 | 49.59
---------+--------+--------+
Case | 596 | 390 | 986
| 30.47 | 19.94 | 50.41
---------+--------+--------+
Total 1206 750 1956
61.66 38.34 100.00
Frequency Missing = 120
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 1.2317 0.2671
Likelihood Ratio Chi-Square 1 1.2320 0.2670
Continuity Adj. Chi-Square 1 1.1307 0.2876
Mantel-Haenszel Chi-Square 1 1.2311 0.2672
Phi Coefficient 0.0251
Contingency Coefficient 0.0251
Cramer's V 0.0251
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 610
Left-sided Pr <= F 0.8762
Right-sided Pr >= F 0.1438
Table Probability (P) 0.0200
Two-sided Pr <= P 0.2848
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.1088 0.9239 1.3306
Cohort (Col1 Risk) 1.0404 0.9701 1.1157
Cohort (Col2 Risk) 0.9383 0.8384 1.0501
Effective Sample Size = 1956
Frequency Missing = 120
European-American Asthma 09:28 Wednesday, August 13, 2003 12
SNP = IIPGA_IL18R1_942
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |AA |GA |GG | Total
---------+--------+--------+--------+
Control | 186 | 238 | 61 | 485
| 19.02 | 24.34 | 6.24 | 49.59
---------+--------+--------+--------+
Case | 182 | 232 | 79 | 493
| 18.61 | 23.72 | 8.08 | 50.41
---------+--------+--------+--------+
Total 368 470 140 978
37.63 48.06 14.31 100.00
Frequency Missing = 60
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 2.3691 0.3059
Likelihood Ratio Chi-Square 2 2.3753 0.3049
Mantel-Haenszel Chi-Square 1 1.2510 0.2634
Phi Coefficient 0.0492
Contingency Coefficient 0.0492
Cramer's V 0.0492
Pearson Chi-Square Test
----------------------------------
Chi-Square 2.3691
DF 2
Asymptotic Pr > ChiSq 0.3059
Exact Pr >= ChiSq 0.3101
Effective Sample Size = 978
Frequency Missing = 60