| Information |
|---|
| interleukin 10 precursor |
| InnateImmunity |
|
chr1 (-) (chr1:205007571-205012462) |
|
NM_000572
|
| 31 |
| 0 |
| 4 |
| 0 |
|
[ SNPper ]
[ GoldenPath ]
[ Gene Image ]
[ LocusLink ]
[ Omim ]
[ PubMed ]
|
|
IL10 is a regulatory cytokine produced by antigen-presenting cells stimulated by bacterial pathogens, as well as human T cells of both Th1 and Th2 phenotype. IL-10 is the only cytokine that is known to exert a differential effect on IL-4-dependent isotype switching to IgE and IgG4. Indeed, IL-10 has been shown to suppress IgE synthesis while enhancing IgG4 expression. Peripheral tolerance has been shown to be critically mediated by IL-10. Single nucleotide polymorphisms in the IL-10 gene have been associated with dysregulated IgE synthesis.
( See Omim for more ... ) |
