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                                                 European-American Asthma              11:50 Wednesday, February 4, 2004  38

                                                     SNP = CD209_11456 

                                                     The FREQ Procedure

                                                 Table of Allele Frequency

                                             Allele Frequency

                                             Frequency|
                                             Percent  |A       |T       |  Total
                                             ---------+--------+--------+
                                             Control  |    140 |    144 |    284
                                                      |  23.49 |  24.16 |  47.65
                                             ---------+--------+--------+
                                             Case     |    149 |    163 |    312
                                                      |  25.00 |  27.35 |  52.35
                                             ---------+--------+--------+
                                             Total         289      307      596
                                                         48.49    51.51   100.00

                                                  Frequency Missing = 1462


                                          Statistics for Table of Allele Frequency

                                   Statistic                     DF       Value      Prob
                                   ------------------------------------------------------
                                   Chi-Square                     1      0.1410    0.7072
                                   Likelihood Ratio Chi-Square    1      0.1410    0.7072
                                   Continuity Adj. Chi-Square     1      0.0861    0.7691
                                   Mantel-Haenszel Chi-Square     1      0.1408    0.7075
                                   Phi Coefficient                       0.0154          
                                   Contingency Coefficient               0.0154          
                                   Cramer's V                            0.0154          


                                                    Fisher's Exact Test
                                             ----------------------------------
                                             Cell (1,1) Frequency (F)       140
                                             Left-sided Pr <= F          0.6764
                                             Right-sided Pr >= F         0.3846
                                                                               
                                             Table Probability (P)       0.0609
                                             Two-sided Pr <= P           0.7429


                                         Estimates of the Relative Risk (Row1/Row2)
 
                              Type of Study                   Value       95% Confidence Limits
                              -----------------------------------------------------------------
                              Case-Control (Odds Ratio)      1.0636        0.7710        1.4671
                              Cohort (Col1 Risk)             1.0322        0.8748        1.2180
                              Cohort (Col2 Risk)             0.9705        0.8302        1.1346

                                                 Effective Sample Size = 596
                                                  Frequency Missing = 1462

                                            WARNING: 71% of the data are missing.
European-American Asthma 11:50 Wednesday, February 4, 2004 39
                                                     SNP = CD209_11456 

                                                     The FREQ Procedure

                                                 Table of Allele Frequency

                                             Allele Frequency

                                             Frequency|
                                             Percent  |1       |4       |  Total
                                             ---------+--------+--------+
                                             Control  |    133 |      9 |    142
                                                      |  44.63 |   3.02 |  47.65
                                             ---------+--------+--------+
                                             Case     |    144 |     12 |    156
                                                      |  48.32 |   4.03 |  52.35
                                             ---------+--------+--------+
                                             Total         277       21      298
                                                         92.95     7.05   100.00

                                                   Frequency Missing = 731


                                          Statistics for Table of Allele Frequency

                                   Statistic                     DF       Value      Prob
                                   ------------------------------------------------------
                                   Chi-Square                     1      0.2081    0.6482
                                   Likelihood Ratio Chi-Square    1      0.2090    0.6475
                                   Continuity Adj. Chi-Square     1      0.0527    0.8184
                                   Mantel-Haenszel Chi-Square     1      0.2074    0.6488
                                   Phi Coefficient                       0.0264          
                                   Contingency Coefficient               0.0264          
                                   Cramer's V                            0.0264          


                                                  Pearson Chi-Square Test
                                             ----------------------------------
                                             Chi-Square                  0.2081
                                             DF                               1
                                             Asymptotic Pr >  ChiSq      0.6482
                                             Exact      Pr >= ChiSq      0.6599


                                                    Fisher's Exact Test
                                             ----------------------------------
                                             Cell (1,1) Frequency (F)       133
                                             Left-sided Pr <= F          0.7516
                                             Right-sided Pr >= F         0.4107
                                                                               
                                             Table Probability (P)       0.1623
                                             Two-sided Pr <= P           0.8214


European-American Asthma 11:50 Wednesday, February 4, 2004 40
                                                     SNP = CD209_11456 

                                                     The FREQ Procedure
 
                                          Statistics for Table of Allele Frequency

                                         Estimates of the Relative Risk (Row1/Row2)
 
                              Type of Study                   Value       95% Confidence Limits
                              -----------------------------------------------------------------
                              Case-Control (Odds Ratio)      1.2315        0.5028        3.0163
                              Cohort (Col1 Risk)             1.0147        0.9534        1.0799
                              Cohort (Col2 Risk)             0.8239        0.3579        1.8968


                                               Odds Ratio (Case-Control Study)
                                             -----------------------------------
                                             Odds Ratio                   1.2315
                                                                                
                                             Asymptotic Conf Limits             
                                             95% Lower Conf Limit         0.5028
                                             95% Upper Conf Limit         3.0163
                                                                                
                                             Exact Conf Limits                  
                                             95% Lower Conf Limit         0.4591
                                             95% Upper Conf Limit         3.4218

                                                 Effective Sample Size = 298
                                                   Frequency Missing = 731

                                            WARNING: 71% of the data are missing.
European-American Asthma 11:50 Wednesday, February 4, 2004 41
                                                      SNP = CD209_4674 

                                                     The FREQ Procedure

                                                 Table of Allele Frequency

                                             Allele Frequency

                                             Frequency|
                                             Percent  |C       |T       |  Total
                                             ---------+--------+--------+
                                             Control  |    195 |    795 |    990
                                                      |   9.85 |  40.15 |  50.00
                                             ---------+--------+--------+
                                             Case     |    194 |    796 |    990
                                                      |   9.80 |  40.20 |  50.00
                                             ---------+--------+--------+
                                             Total         389     1591     1980
                                                         19.65    80.35   100.00

                                                   Frequency Missing = 78


                                          Statistics for Table of Allele Frequency

                                   Statistic                     DF       Value      Prob
                                   ------------------------------------------------------
                                   Chi-Square                     1      0.0032    0.9549
                                   Likelihood Ratio Chi-Square    1      0.0032    0.9549
                                   Continuity Adj. Chi-Square     1      0.0000    1.0000
                                   Mantel-Haenszel Chi-Square     1      0.0032    0.9549
                                   Phi Coefficient                       0.0013          
                                   Contingency Coefficient               0.0013          
                                   Cramer's V                            0.0013          


                                                    Fisher's Exact Test
                                             ----------------------------------
                                             Cell (1,1) Frequency (F)       195
                                             Left-sided Pr <= F          0.5450
                                             Right-sided Pr >= F         0.5000
                                                                               
                                             Table Probability (P)       0.0450
                                             Two-sided Pr <= P           1.0000


                                         Estimates of the Relative Risk (Row1/Row2)
 
                              Type of Study                   Value       95% Confidence Limits
                              -----------------------------------------------------------------
                              Case-Control (Odds Ratio)      1.0064        0.8063        1.2562
                              Cohort (Col1 Risk)             1.0052        0.8411        1.2012
                              Cohort (Col2 Risk)             0.9987        0.9562        1.0432

                                                Effective Sample Size = 1980
                                                   Frequency Missing = 78
European-American Asthma 11:50 Wednesday, February 4, 2004 42
                                                      SNP = CD209_4674 

                                                     The FREQ Procedure

                                                 Table of Allele Frequency

                                             Allele Frequency

                                             Frequency|
                                             Percent  |2       |4       |  Total
                                             ---------+--------+--------+
                                             Control  |     18 |    477 |    495
                                                      |   1.82 |  48.18 |  50.00
                                             ---------+--------+--------+
                                             Case     |     21 |    474 |    495
                                                      |   2.12 |  47.88 |  50.00
                                             ---------+--------+--------+
                                             Total          39      951      990
                                                          3.94    96.06   100.00

                                                   Frequency Missing = 39


                                          Statistics for Table of Allele Frequency

                                   Statistic                     DF       Value      Prob
                                   ------------------------------------------------------
                                   Chi-Square                     1      0.2402    0.6240
                                   Likelihood Ratio Chi-Square    1      0.2405    0.6239
                                   Continuity Adj. Chi-Square     1      0.1068    0.7439
                                   Mantel-Haenszel Chi-Square     1      0.2400    0.6242
                                   Phi Coefficient                      -0.0156          
                                   Contingency Coefficient               0.0156          
                                   Cramer's V                           -0.0156          


                                                  Pearson Chi-Square Test
                                             ----------------------------------
                                             Chi-Square                  0.2402
                                             DF                               1
                                             Asymptotic Pr >  ChiSq      0.6240
                                             Exact      Pr >= ChiSq      0.7443


                                                    Fisher's Exact Test
                                             ----------------------------------
                                             Cell (1,1) Frequency (F)        18
                                             Left-sided Pr <= F          0.3722
                                             Right-sided Pr >= F         0.7430
                                                                               
                                             Table Probability (P)       0.1152
                                             Two-sided Pr <= P           0.7443


European-American Asthma 11:50 Wednesday, February 4, 2004 43
                                                      SNP = CD209_4674 

                                                     The FREQ Procedure
 
                                          Statistics for Table of Allele Frequency

                                         Estimates of the Relative Risk (Row1/Row2)
 
                              Type of Study                   Value       95% Confidence Limits
                              -----------------------------------------------------------------
                              Case-Control (Odds Ratio)      0.8518        0.4481        1.6190
                              Cohort (Col1 Risk)             0.8571        0.4624        1.5888
                              Cohort (Col2 Risk)             1.0063        0.9813        1.0320


                                               Odds Ratio (Case-Control Study)
                                             -----------------------------------
                                             Odds Ratio                   0.8518
                                                                                
                                             Asymptotic Conf Limits             
                                             95% Lower Conf Limit         0.4481
                                             95% Upper Conf Limit         1.6190
                                                                                
                                             Exact Conf Limits                  
                                             95% Lower Conf Limit         0.4220
                                             95% Upper Conf Limit         1.7032

                                                 Effective Sample Size = 990
                                                   Frequency Missing = 39
European-American Asthma 11:50 Wednesday, February 4, 2004 44
                                                      SNP = CD209_4871 

                                                     The FREQ Procedure

                                                 Table of Allele Frequency

                                             Allele Frequency

                                             Frequency|
                                             Percent  |C       |T       |  Total
                                             ---------+--------+--------+
                                             Control  |    614 |    336 |    950
                                                      |  32.38 |  17.72 |  50.11
                                             ---------+--------+--------+
                                             Case     |    628 |    318 |    946
                                                      |  33.12 |  16.77 |  49.89
                                             ---------+--------+--------+
                                             Total        1242      654     1896
                                                         65.51    34.49   100.00

                                                   Frequency Missing = 162


                                          Statistics for Table of Allele Frequency

                                   Statistic                     DF       Value      Prob
                                   ------------------------------------------------------
                                   Chi-Square                     1      0.6448    0.4220
                                   Likelihood Ratio Chi-Square    1      0.6448    0.4220
                                   Continuity Adj. Chi-Square     1      0.5695    0.4504
                                   Mantel-Haenszel Chi-Square     1      0.6444    0.4221
                                   Phi Coefficient                      -0.0184          
                                   Contingency Coefficient               0.0184          
                                   Cramer's V                           -0.0184          


                                                    Fisher's Exact Test
                                             ----------------------------------
                                             Cell (1,1) Frequency (F)       614
                                             Left-sided Pr <= F          0.2252
                                             Right-sided Pr >= F         0.8027
                                                                               
                                             Table Probability (P)       0.0279
                                             Two-sided Pr <= P           0.4396


                                         Estimates of the Relative Risk (Row1/Row2)
 
                              Type of Study                   Value       95% Confidence Limits
                              -----------------------------------------------------------------
                              Case-Control (Odds Ratio)      0.9253        0.7656        1.1183
                              Cohort (Col1 Risk)             0.9736        0.9120        1.0393
                              Cohort (Col2 Risk)             1.0522        0.9293        1.1912

                                                Effective Sample Size = 1896
                                                   Frequency Missing = 162
European-American Asthma 11:50 Wednesday, February 4, 2004 45
                                                      SNP = CD209_4871 

                                                     The FREQ Procedure

                                                 Table of Allele Frequency

                                             Allele Frequency

                                             Frequency|
                                             Percent  |2       |4       |  Total
                                             ---------+--------+--------+
                                             Control  |    199 |    276 |    475
                                                      |  20.99 |  29.11 |  50.11
                                             ---------+--------+--------+
                                             Case     |    205 |    268 |    473
                                                      |  21.62 |  28.27 |  49.89
                                             ---------+--------+--------+
                                             Total         404      544      948
                                                         42.62    57.38   100.00

                                                   Frequency Missing = 81


                                          Statistics for Table of Allele Frequency

                                   Statistic                     DF       Value      Prob
                                   ------------------------------------------------------
                                   Chi-Square                     1      0.2025    0.6527
                                   Likelihood Ratio Chi-Square    1      0.2025    0.6527
                                   Continuity Adj. Chi-Square     1      0.1477    0.7007
                                   Mantel-Haenszel Chi-Square     1      0.2023    0.6529
                                   Phi Coefficient                      -0.0146          
                                   Contingency Coefficient               0.0146          
                                   Cramer's V                           -0.0146          


                                                  Pearson Chi-Square Test
                                             ----------------------------------
                                             Chi-Square                  0.2025
                                             DF                               1
                                             Asymptotic Pr >  ChiSq      0.6527
                                             Exact      Pr >= ChiSq      0.6936


                                                    Fisher's Exact Test
                                             ----------------------------------
                                             Cell (1,1) Frequency (F)       199
                                             Left-sided Pr <= F          0.3504
                                             Right-sided Pr >= F         0.6970
                                                                               
                                             Table Probability (P)       0.0473
                                             Two-sided Pr <= P           0.6936


European-American Asthma 11:50 Wednesday, February 4, 2004 46
                                                      SNP = CD209_4871 

                                                     The FREQ Procedure
 
                                          Statistics for Table of Allele Frequency

                                         Estimates of the Relative Risk (Row1/Row2)
 
                              Type of Study                   Value       95% Confidence Limits
                              -----------------------------------------------------------------
                              Case-Control (Odds Ratio)      0.9426        0.7286        1.2194
                              Cohort (Col1 Risk)             0.9666        0.8339        1.1206
                              Cohort (Col2 Risk)             1.0255        0.9189        1.1445


                                               Odds Ratio (Case-Control Study)
                                             -----------------------------------
                                             Odds Ratio                   0.9426
                                                                                
                                             Asymptotic Conf Limits             
                                             95% Lower Conf Limit         0.7286
                                             95% Upper Conf Limit         1.2194
                                                                                
                                             Exact Conf Limits                  
                                             95% Lower Conf Limit         0.7225
                                             95% Upper Conf Limit         1.2297

                                                 Effective Sample Size = 948
                                                   Frequency Missing = 81




   
 
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