Innate Immunity in Heart, Lung and Blood Disease
Programs for Genomic Applications
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European-American Asthma 11:50 Wednesday, February 4, 2004 5
SNP = CCL24_5179
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |C |T | Total
---------+--------+--------+
Control | 365 | 509 | 874
| 20.44 | 28.50 | 48.94
---------+--------+--------+
Case | 398 | 514 | 912
| 22.28 | 28.78 | 51.06
---------+--------+--------+
Total 763 1023 1786
42.72 57.28 100.00
Frequency Missing = 270
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.6435 0.4225
Likelihood Ratio Chi-Square 1 0.6436 0.4224
Continuity Adj. Chi-Square 1 0.5690 0.4507
Mantel-Haenszel Chi-Square 1 0.6431 0.4226
Phi Coefficient -0.0190
Contingency Coefficient 0.0190
Cramer's V -0.0190
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 365
Left-sided Pr <= F 0.2253
Right-sided Pr >= F 0.8023
Table Probability (P) 0.0277
Two-sided Pr <= P 0.4440
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 0.9261 0.7677 1.1172
Cohort (Col1 Risk) 0.9570 0.8594 1.0656
Cohort (Col2 Risk) 1.0333 0.9538 1.1195
Effective Sample Size = 1786
Frequency Missing = 270
WARNING: 13% of the data are missing.
European-American Asthma 11:50 Wednesday, February 4, 2004 6
SNP = CCL24_5179
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |2 |4 | Total
---------+--------+--------+
Control | 76 | 361 | 437
| 8.51 | 40.43 | 48.94
---------+--------+--------+
Case | 85 | 371 | 456
| 9.52 | 41.55 | 51.06
---------+--------+--------+
Total 161 732 893
18.03 81.97 100.00
Frequency Missing = 135
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.2356 0.6274
Likelihood Ratio Chi-Square 1 0.2357 0.6273
Continuity Adj. Chi-Square 1 0.1586 0.6904
Mantel-Haenszel Chi-Square 1 0.2353 0.6276
Phi Coefficient -0.0162
Contingency Coefficient 0.0162
Cramer's V -0.0162
Pearson Chi-Square Test
----------------------------------
Chi-Square 0.2356
DF 1
Asymptotic Pr > ChiSq 0.6274
Exact Pr >= ChiSq 0.6636
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 76
Left-sided Pr <= F 0.3454
Right-sided Pr >= F 0.7163
Table Probability (P) 0.0617
Two-sided Pr <= P 0.6636
European-American Asthma 11:50 Wednesday, February 4, 2004 7
SNP = CCL24_5179
The FREQ Procedure
Statistics for Table of Allele Frequency
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 0.9189 0.6529 1.2931
Cohort (Col1 Risk) 0.9330 0.7050 1.2347
Cohort (Col2 Risk) 1.0154 0.9548 1.0797
Odds Ratio (Case-Control Study)
-----------------------------------
Odds Ratio 0.9189
Asymptotic Conf Limits
95% Lower Conf Limit 0.6529
95% Upper Conf Limit 1.2931
Exact Conf Limits
95% Lower Conf Limit 0.6429
95% Upper Conf Limit 1.3119
Effective Sample Size = 893
Frequency Missing = 135
WARNING: 13% of the data are missing.
European-American Asthma 11:50 Wednesday, February 4, 2004 8
SNP = CCL24_5304
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |A |C | Total
---------+--------+--------+
Control | 769 | 175 | 944
| 40.86 | 9.30 | 50.16
---------+--------+--------+
Case | 754 | 184 | 938
| 40.06 | 9.78 | 49.84
---------+--------+--------+
Total 1523 359 1882
80.92 19.08 100.00
Frequency Missing = 174
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.3542 0.5517
Likelihood Ratio Chi-Square 1 0.3543 0.5517
Continuity Adj. Chi-Square 1 0.2878 0.5916
Mantel-Haenszel Chi-Square 1 0.3540 0.5518
Phi Coefficient 0.0137
Contingency Coefficient 0.0137
Cramer's V 0.0137
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 769
Left-sided Pr <= F 0.7434
Right-sided Pr >= F 0.2958
Table Probability (P) 0.0392
Two-sided Pr <= P 0.5579
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.0723 0.8520 1.3497
Cohort (Col1 Risk) 1.0134 0.9699 1.0589
Cohort (Col2 Risk) 0.9450 0.7845 1.1384
Effective Sample Size = 1882
Frequency Missing = 174
European-American Asthma 11:50 Wednesday, February 4, 2004 9
SNP = CCL24_5304
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |1 |2 | Total
---------+--------+--------+
Control | 313 | 159 | 472
| 33.26 | 16.90 | 50.16
---------+--------+--------+
Case | 307 | 162 | 469
| 32.62 | 17.22 | 49.84
---------+--------+--------+
Total 620 321 941
65.89 34.11 100.00
Frequency Missing = 87
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.0765 0.7820
Likelihood Ratio Chi-Square 1 0.0765 0.7820
Continuity Adj. Chi-Square 1 0.0432 0.8353
Mantel-Haenszel Chi-Square 1 0.0765 0.7822
Phi Coefficient 0.0090
Contingency Coefficient 0.0090
Cramer's V 0.0090
Pearson Chi-Square Test
----------------------------------
Chi-Square 0.0765
DF 1
Asymptotic Pr > ChiSq 0.7820
Exact Pr >= ChiSq 0.7838
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 313
Left-sided Pr <= F 0.6351
Right-sided Pr >= F 0.4177
Table Probability (P) 0.0528
Two-sided Pr <= P 0.7838
European-American Asthma 11:50 Wednesday, February 4, 2004 10
SNP = CCL24_5304
The FREQ Procedure
Statistics for Table of Allele Frequency
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.0388 0.7933 1.3602
Cohort (Col1 Risk) 1.0131 0.9241 1.1106
Cohort (Col2 Risk) 0.9752 0.8165 1.1648
Odds Ratio (Case-Control Study)
-----------------------------------
Odds Ratio 1.0388
Asymptotic Conf Limits
95% Lower Conf Limit 0.7933
95% Upper Conf Limit 1.3602
Exact Conf Limits
95% Lower Conf Limit 0.7861
95% Upper Conf Limit 1.3728
Effective Sample Size = 941
Frequency Missing = 87
European-American Asthma 11:50 Wednesday, February 4, 2004 11
SNP = CCL24_5311
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |C |T | Total
---------+--------+--------+
Control | 901 | 41 | 942
| 47.98 | 2.18 | 50.16
---------+--------+--------+
Case | 907 | 29 | 936
| 48.30 | 1.54 | 49.84
---------+--------+--------+
Total 1808 70 1878
96.27 3.73 100.00
Frequency Missing = 178
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 2.0579 0.1514
Likelihood Ratio Chi-Square 1 2.0681 0.1504
Continuity Adj. Chi-Square 1 1.7232 0.1893
Mantel-Haenszel Chi-Square 1 2.0568 0.1515
Phi Coefficient -0.0331
Contingency Coefficient 0.0331
Cramer's V -0.0331
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 901
Left-sided Pr <= F 0.0944
Right-sided Pr >= F 0.9405
Table Probability (P) 0.0349
Two-sided Pr <= P 0.1800
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 0.7026 0.4329 1.1405
Cohort (Col1 Risk) 0.9871 0.9696 1.0048
Cohort (Col2 Risk) 1.4048 0.8807 2.2406
Effective Sample Size = 1878
Frequency Missing = 178
European-American Asthma 11:50 Wednesday, February 4, 2004 12
SNP = CCL24_5311
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |2 |4 | Total
---------+--------+--------+
Control | 434 | 37 | 471
| 46.22 | 3.94 | 50.16
---------+--------+--------+
Case | 439 | 29 | 468
| 46.75 | 3.09 | 49.84
---------+--------+--------+
Total 873 66 939
92.97 7.03 100.00
Frequency Missing = 89
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.9888 0.3200
Likelihood Ratio Chi-Square 1 0.9911 0.3195
Continuity Adj. Chi-Square 1 0.7512 0.3861
Mantel-Haenszel Chi-Square 1 0.9877 0.3203
Phi Coefficient -0.0324
Contingency Coefficient 0.0324
Cramer's V -0.0324
Pearson Chi-Square Test
----------------------------------
Chi-Square 0.9888
DF 1
Asymptotic Pr > ChiSq 0.3200
Exact Pr >= ChiSq 0.3718
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 434
Left-sided Pr <= F 0.1931
Right-sided Pr >= F 0.8691
Table Probability (P) 0.0623
Two-sided Pr <= P 0.3718
European-American Asthma 11:50 Wednesday, February 4, 2004 13
SNP = CCL24_5311
The FREQ Procedure
Statistics for Table of Allele Frequency
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 0.7749 0.4682 1.2825
Cohort (Col1 Risk) 0.9823 0.9484 1.0175
Cohort (Col2 Risk) 1.2677 0.7932 2.0263
Odds Ratio (Case-Control Study)
-----------------------------------
Odds Ratio 0.7749
Asymptotic Conf Limits
95% Lower Conf Limit 0.4682
95% Upper Conf Limit 1.2825
Exact Conf Limits
95% Lower Conf Limit 0.4510
95% Upper Conf Limit 1.3209
Effective Sample Size = 939
Frequency Missing = 89
European-American Asthma 11:50 Wednesday, February 4, 2004 14
SNP = CCL24_5447
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |C |T | Total
---------+--------+--------+
Control | 252 | 710 | 962
| 13.19 | 37.17 | 50.37
---------+--------+--------+
Case | 238 | 710 | 948
| 12.46 | 37.17 | 49.63
---------+--------+--------+
Total 490 1420 1910
25.65 74.35 100.00
Frequency Missing = 146
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.2974 0.5855
Likelihood Ratio Chi-Square 1 0.2974 0.5855
Continuity Adj. Chi-Square 1 0.2430 0.6220
Mantel-Haenszel Chi-Square 1 0.2972 0.5856
Phi Coefficient 0.0125
Contingency Coefficient 0.0125
Cramer's V 0.0125
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 252
Left-sided Pr <= F 0.7250
Right-sided Pr >= F 0.3111
Table Probability (P) 0.0360
Two-sided Pr <= P 0.6005
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.0588 0.8622 1.3003
Cohort (Col1 Risk) 1.0434 0.8956 1.2156
Cohort (Col2 Risk) 0.9854 0.9349 1.0388
Effective Sample Size = 1910
Frequency Missing = 146
European-American Asthma 11:50 Wednesday, February 4, 2004 15
SNP = CCL24_5447
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |2 |4 | Total
---------+--------+--------+
Control | 30 | 451 | 481
| 3.14 | 47.23 | 50.37
---------+--------+--------+
Case | 23 | 451 | 474
| 2.41 | 47.23 | 49.63
---------+--------+--------+
Total 53 902 955
5.55 94.45 100.00
Frequency Missing = 73
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.8733 0.3501
Likelihood Ratio Chi-Square 1 0.8759 0.3493
Continuity Adj. Chi-Square 1 0.6291 0.4277
Mantel-Haenszel Chi-Square 1 0.8724 0.3503
Phi Coefficient 0.0302
Contingency Coefficient 0.0302
Cramer's V 0.0302
Pearson Chi-Square Test
----------------------------------
Chi-Square 0.8733
DF 1
Asymptotic Pr > ChiSq 0.3501
Exact Pr >= ChiSq 0.3973
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 30
Left-sided Pr <= F 0.8591
Right-sided Pr >= F 0.2140
Table Probability (P) 0.0731
Two-sided Pr <= P 0.3973
European-American Asthma 11:50 Wednesday, February 4, 2004 16
SNP = CCL24_5447
The FREQ Procedure
Statistics for Table of Allele Frequency
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.3043 0.7461 2.2804
Cohort (Col1 Risk) 1.2854 0.7579 2.1798
Cohort (Col2 Risk) 0.9854 0.9556 1.0162
Odds Ratio (Case-Control Study)
-----------------------------------
Odds Ratio 1.3043
Asymptotic Conf Limits
95% Lower Conf Limit 0.7461
95% Upper Conf Limit 2.2804
Exact Conf Limits
95% Lower Conf Limit 0.7198
95% Upper Conf Limit 2.3902
Effective Sample Size = 955
Frequency Missing = 73
European-American Asthma 11:50 Wednesday, February 4, 2004 17
SNP = CCL24_6923
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |A |C | Total
---------+--------+--------+
Control | 451 | 477 | 928
| 24.51 | 25.92 | 50.43
---------+--------+--------+
Case | 426 | 486 | 912
| 23.15 | 26.41 | 49.57
---------+--------+--------+
Total 877 963 1840
47.66 52.34 100.00
Frequency Missing = 216
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.6577 0.4174
Likelihood Ratio Chi-Square 1 0.6577 0.4174
Continuity Adj. Chi-Square 1 0.5842 0.4447
Mantel-Haenszel Chi-Square 1 0.6573 0.4175
Phi Coefficient 0.0189
Contingency Coefficient 0.0189
Cramer's V 0.0189
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 451
Left-sided Pr <= F 0.8045
Right-sided Pr >= F 0.2223
Table Probability (P) 0.0268
Two-sided Pr <= P 0.4277
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.0787 0.8983 1.2953
Cohort (Col1 Risk) 1.0404 0.9454 1.1451
Cohort (Col2 Risk) 0.9646 0.8840 1.0525
Effective Sample Size = 1840
Frequency Missing = 216
WARNING: 11% of the data are missing.
European-American Asthma 11:50 Wednesday, February 4, 2004 18
SNP = CCL24_6923
The FREQ Procedure
Table of Allele Frequency
Allele Frequency
Frequency|
Percent |1 |2 | Total
---------+--------+--------+
Control | 94 | 370 | 464
| 10.22 | 40.22 | 50.43
---------+--------+--------+
Case | 103 | 353 | 456
| 11.20 | 38.37 | 49.57
---------+--------+--------+
Total 197 723 920
21.41 78.59 100.00
Frequency Missing = 108
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.7414 0.3892
Likelihood Ratio Chi-Square 1 0.7415 0.3892
Continuity Adj. Chi-Square 1 0.6094 0.4350
Mantel-Haenszel Chi-Square 1 0.7406 0.3895
Phi Coefficient -0.0284
Contingency Coefficient 0.0284
Cramer's V -0.0284
Pearson Chi-Square Test
----------------------------------
Chi-Square 0.7414
DF 1
Asymptotic Pr > ChiSq 0.3892
Exact Pr >= ChiSq 0.4217
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 94
Left-sided Pr <= F 0.2175
Right-sided Pr >= F 0.8267
Table Probability (P) 0.0443
Two-sided Pr <= P 0.4217
European-American Asthma 11:50 Wednesday, February 4, 2004 19
SNP = CCL24_6923
The FREQ Procedure
Statistics for Table of Allele Frequency
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 0.8707 0.6352 1.1935
Cohort (Col1 Risk) 0.8969 0.7000 1.1492
Cohort (Col2 Risk) 1.0301 0.9628 1.1021
Odds Ratio (Case-Control Study)
-----------------------------------
Odds Ratio 0.8707
Asymptotic Conf Limits
95% Lower Conf Limit 0.6352
95% Upper Conf Limit 1.1935
Exact Conf Limits
95% Lower Conf Limit 0.6270
95% Upper Conf Limit 1.2084
Effective Sample Size = 920
Frequency Missing = 108
WARNING: 11% of the data are missing.