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European-American COPD 13:43 Monday, May 6, 2002 3
SNP = NOD2-001681
Allele Frequency
Frequency|
Percent |A |G | Total
---------+--------+--------+
Case | 73 | 219 | 292
| 17.55 | 52.64 | 70.19
---------+--------+--------+
Control | 40 | 84 | 124
| 9.62 | 20.19 | 29.81
---------+--------+--------+
Total 113 303 416
27.16 72.84 100.00
Frequency Missing = 34
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 2.3175 0.1279
Likelihood Ratio Chi-Square 1 2.2724 0.1317
Continuity Adj. Chi-Square 1 1.9652 0.1610
Mantel-Haenszel Chi-Square 1 2.3119 0.1284
Phi Coefficient -0.0746
Contingency Coefficient 0.0744
Cramer's V -0.0746
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 73
Left-sided Pr <= F 0.0814
Right-sided Pr >= F 0.9487
Table Probability (P) 0.0301
Two-sided Pr <= P 0.1482
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 0.7000 0.4417 1.1093
Cohort (Col1 Risk) 0.7750 0.5609 1.0708
Cohort (Col2 Risk) 1.1071 0.9641 1.2714
Effective Sample Size = 416
Frequency Missing = 34
European-American COPD 13:43 Monday, May 6, 2002 4
SNP = NOD2-001681
Allele Frequency
Frequency|
Percent |AA |GA |GG | Total
---------+--------+--------+--------+
Case | 9 | 55 | 82 | 146
| 4.33 | 26.44 | 39.42 | 70.19
---------+--------+--------+--------+
Control | 3 | 34 | 25 | 62
| 1.44 | 16.35 | 12.02 | 29.81
---------+--------+--------+--------+
Total 12 89 107 208
5.77 42.79 51.44 100.00
Frequency Missing = 17
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 5.2532 0.0723
Likelihood Ratio Chi-Square 2 5.2243 0.0734
Mantel-Haenszel Chi-Square 1 2.5106 0.1131
Phi Coefficient 0.1589
Contingency Coefficient 0.1570
Cramer's V 0.1589
Pearson Chi-Square Test
----------------------------------
Chi-Square 5.2532
DF 2
Asymptotic Pr > ChiSq 0.0723
Exact Pr >= ChiSq 0.0799
Effective Sample Size = 208
Frequency Missing = 17
European-American COPD 13:43 Monday, May 6, 2002 5
SNP = NOD2-004827
Allele Frequency
Frequency|
Percent |G |T | Total
---------+--------+--------+
Case | 220 | 70 | 290
| 52.63 | 16.75 | 69.38
---------+--------+--------+
Control | 92 | 36 | 128
| 22.01 | 8.61 | 30.62
---------+--------+--------+
Total 312 106 418
74.64 25.36 100.00
Frequency Missing = 32
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.7458 0.3878
Likelihood Ratio Chi-Square 1 0.7366 0.3907
Continuity Adj. Chi-Square 1 0.5500 0.4583
Mantel-Haenszel Chi-Square 1 0.7440 0.3884
Phi Coefficient 0.0422
Contingency Coefficient 0.0422
Cramer's V 0.0422
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 220
Left-sided Pr <= F 0.8379
Right-sided Pr >= F 0.2281
Table Probability (P) 0.0660
Two-sided Pr <= P 0.3954
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.2298 0.7687 1.9675
Cohort (Col1 Risk) 1.0555 0.9302 1.1976
Cohort (Col2 Risk) 0.8582 0.6084 1.2106
Effective Sample Size = 418
Frequency Missing = 32
European-American COPD 13:43 Monday, May 6, 2002 6
SNP = NOD2-004827
Allele Frequency
Frequency|
Percent |GG |GT |TT | Total
---------+--------+--------+--------+
Case | 82 | 56 | 7 | 145
| 39.23 | 26.79 | 3.35 | 69.38
---------+--------+--------+--------+
Control | 30 | 32 | 2 | 64
| 14.35 | 15.31 | 0.96 | 30.62
---------+--------+--------+--------+
Total 112 88 9 209
53.59 42.11 4.31 100.00
Frequency Missing = 16
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 2.4403 0.2952
Likelihood Ratio Chi-Square 2 2.4364 0.2958
Mantel-Haenszel Chi-Square 1 0.8361 0.3605
Phi Coefficient 0.1081
Contingency Coefficient 0.1074
Cramer's V 0.1081
Pearson Chi-Square Test
----------------------------------
Chi-Square 2.4403
DF 2
Asymptotic Pr > ChiSq 0.2952
Exact Pr >= ChiSq 0.3046
Effective Sample Size = 209
Frequency Missing = 16
European-American COPD 13:43 Monday, May 6, 2002 7
SNP = NOD2-016077
Allele Frequency
Frequency|
Percent |C |T | Total
---------+--------+--------+
Case | 227 | 63 | 290
| 54.57 | 15.14 | 69.71
---------+--------+--------+
Control | 87 | 39 | 126
| 20.91 | 9.38 | 30.29
---------+--------+--------+
Total 314 102 416
75.48 24.52 100.00
Frequency Missing = 34
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 4.0418 0.0444
Likelihood Ratio Chi-Square 1 3.9310 0.0474
Continuity Adj. Chi-Square 1 3.5585 0.0592
Mantel-Haenszel Chi-Square 1 4.0320 0.0446
Phi Coefficient 0.0986
Contingency Coefficient 0.0981
Cramer's V 0.0986
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 227
Left-sided Pr <= F 0.9826
Right-sided Pr >= F 0.0308
Table Probability (P) 0.0134
Two-sided Pr <= P 0.0480
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.6152 1.0099 2.5834
Cohort (Col1 Risk) 1.1337 0.9938 1.2932
Cohort (Col2 Risk) 0.7019 0.4995 0.9863
Effective Sample Size = 416
Frequency Missing = 34
European-American COPD 13:43 Monday, May 6, 2002 8
SNP = NOD2-016077
Allele Frequency
Frequency|
Percent |CC |CT |TT | Total
---------+--------+--------+--------+
Case | 88 | 51 | 6 | 145
| 42.31 | 24.52 | 2.88 | 69.71
---------+--------+--------+--------+
Control | 26 | 35 | 2 | 63
| 12.50 | 16.83 | 0.96 | 30.29
---------+--------+--------+--------+
Total 114 86 8 208
54.81 41.35 3.85 100.00
Frequency Missing = 17
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 7.5411 0.0230
Likelihood Ratio Chi-Square 2 7.4826 0.0237
Mantel-Haenszel Chi-Square 1 4.5554 0.0328
Phi Coefficient 0.1904
Contingency Coefficient 0.1870
Cramer's V 0.1904
Pearson Chi-Square Test
----------------------------------
Chi-Square 7.5411
DF 2
Asymptotic Pr > ChiSq 0.0230
Exact Pr >= ChiSq 0.0244
Effective Sample Size = 208
Frequency Missing = 17
European-American COPD 13:43 Monday, May 6, 2002 9
SNP = NOD2-031000
Allele Frequency
Frequency|
Percent |A |T | Total
---------+--------+--------+
Case | 112 | 176 | 288
| 27.05 | 42.51 | 69.57
---------+--------+--------+
Control | 59 | 67 | 126
| 14.25 | 16.18 | 30.43
---------+--------+--------+
Total 171 243 414
41.30 58.70 100.00
Frequency Missing = 36
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 2.2773 0.1313
Likelihood Ratio Chi-Square 1 2.2643 0.1324
Continuity Adj. Chi-Square 1 1.9617 0.1613
Mantel-Haenszel Chi-Square 1 2.2718 0.1317
Phi Coefficient -0.0742
Contingency Coefficient 0.0740
Cramer's V -0.0742
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 112
Left-sided Pr <= F 0.0809
Right-sided Pr >= F 0.9468
Table Probability (P) 0.0277
Two-sided Pr <= P 0.1584
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 0.7227 0.4736 1.1027
Cohort (Col1 Risk) 0.8305 0.6561 1.0513
Cohort (Col2 Risk) 1.1493 0.9523 1.3869
Effective Sample Size = 414
Frequency Missing = 36
European-American COPD 13:43 Monday, May 6, 2002 10
SNP = NOD2-031000
Allele Frequency
Frequency|
Percent |AA |TA |TT | Total
---------+--------+--------+--------+
Case | 15 | 82 | 47 | 144
| 7.25 | 39.61 | 22.71 | 69.57
---------+--------+--------+--------+
Control | 10 | 39 | 14 | 63
| 4.83 | 18.84 | 6.76 | 30.43
---------+--------+--------+--------+
Total 25 121 61 207
12.08 58.45 29.47 100.00
Frequency Missing = 18
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 2.8786 0.2371
Likelihood Ratio Chi-Square 2 2.9131 0.2330
Mantel-Haenszel Chi-Square 1 2.8526 0.0912
Phi Coefficient 0.1179
Contingency Coefficient 0.1171
Cramer's V 0.1179
Pearson Chi-Square Test
----------------------------------
Chi-Square 2.8786
DF 2
Asymptotic Pr > ChiSq 0.2371
Exact Pr >= ChiSq 0.2350
Effective Sample Size = 207
Frequency Missing = 18
European-American COPD 13:43 Monday, May 6, 2002 11
SNP = NOD2-031184
Allele Frequency
Frequency|
Percent |A |T | Total
---------+--------+--------+
Case | 12 | 280 | 292
| 2.86 | 66.67 | 69.52
---------+--------+--------+
Control | 3 | 125 | 128
| 0.71 | 29.76 | 30.48
---------+--------+--------+
Total 15 405 420
3.57 96.43 100.00
Frequency Missing = 30
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.8057 0.3694
Likelihood Ratio Chi-Square 1 0.8700 0.3510
Continuity Adj. Chi-Square 1 0.3746 0.5405
Mantel-Haenszel Chi-Square 1 0.8038 0.3700
Phi Coefficient 0.0438
Contingency Coefficient 0.0438
Cramer's V 0.0438
WARNING: 25% of the cells have expected counts less
than 5. Chi-Square may not be a valid test.
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 12
Left-sided Pr <= F 0.8855
Right-sided Pr >= F 0.2788
Table Probability (P) 0.1643
Two-sided Pr <= P 0.5686
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.7857 0.4952 6.4393
Cohort (Col1 Risk) 1.7534 0.5034 6.1077
Cohort (Col2 Risk) 0.9819 0.9474 1.0177
Effective Sample Size = 420
Frequency Missing = 30
European-American COPD 13:43 Monday, May 6, 2002 12
SNP = NOD2-031184
Allele Frequency
Frequency|
Percent |AA |TA |TT | Total
---------+--------+--------+--------+
Case | 1 | 10 | 135 | 146
| 0.48 | 4.76 | 64.29 | 69.52
---------+--------+--------+--------+
Control | 0 | 3 | 61 | 64
| 0.00 | 1.43 | 29.05 | 30.48
---------+--------+--------+--------+
Total 1 13 196 210
0.48 6.19 93.33 100.00
Frequency Missing = 15
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 0.8129 0.6660
Likelihood Ratio Chi-Square 2 1.1195 0.5713
Mantel-Haenszel Chi-Square 1 0.7282 0.3935
Phi Coefficient 0.0622
Contingency Coefficient 0.0621
Cramer's V 0.0622
WARNING: 50% of the cells have expected counts less than 5.
(Asymptotic) Chi-Square may not be a valid test.
Pearson Chi-Square Test
----------------------------------
Chi-Square 0.8129
DF 2
Asymptotic Pr > ChiSq 0.6660
Exact Pr >= ChiSq 0.8319
Effective Sample Size = 210
Frequency Missing = 15
European-American Asthma 13:43 Monday, May 6, 2002 13
SNP = NOD2-001681
Allele Frequency
Frequency|
Percent |A |G | Total
---------+--------+--------+
Case | 83 | 221 | 304
| 17.97 | 47.84 | 65.80
---------+--------+--------+
Control | 49 | 109 | 158
| 10.61 | 23.59 | 34.20
---------+--------+--------+
Total 132 330 462
28.57 71.43 100.00
Frequency Missing = 26
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.7012 0.4024
Likelihood Ratio Chi-Square 1 0.6959 0.4042
Continuity Adj. Chi-Square 1 0.5312 0.4661
Mantel-Haenszel Chi-Square 1 0.6997 0.4029
Phi Coefficient -0.0390
Contingency Coefficient 0.0389
Cramer's V -0.0390
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 83
Left-sided Pr <= F 0.2324
Right-sided Pr >= F 0.8280
Table Probability (P) 0.0604
Two-sided Pr <= P 0.4475
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 0.8354 0.5483 1.2729
Cohort (Col1 Risk) 0.8804 0.6547 1.1839
Cohort (Col2 Risk) 1.0538 0.9298 1.1943
Effective Sample Size = 462
Frequency Missing = 26
European-American Asthma 13:43 Monday, May 6, 2002 14
SNP = NOD2-001681
Allele Frequency
Frequency|
Percent |AA |GA |GG | Total
---------+--------+--------+--------+
Case | 12 | 59 | 81 | 152
| 5.19 | 25.54 | 35.06 | 65.80
---------+--------+--------+--------+
Control | 5 | 39 | 35 | 79
| 2.16 | 16.88 | 15.15 | 34.20
---------+--------+--------+--------+
Total 17 98 116 231
7.36 42.42 50.22 100.00
Frequency Missing = 13
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 2.3731 0.3053
Likelihood Ratio Chi-Square 2 2.3632 0.3068
Mantel-Haenszel Chi-Square 1 0.7268 0.3939
Phi Coefficient 0.1014
Contingency Coefficient 0.1008
Cramer's V 0.1014
Pearson Chi-Square Test
----------------------------------
Chi-Square 2.3731
DF 2
Asymptotic Pr > ChiSq 0.3053
Exact Pr >= ChiSq 0.3212
Effective Sample Size = 231
Frequency Missing = 13
European-American Asthma 13:43 Monday, May 6, 2002 15
SNP = NOD2-004827
Allele Frequency
Frequency|
Percent |G |T | Total
---------+--------+--------+
Case | 227 | 77 | 304
| 49.13 | 16.67 | 65.80
---------+--------+--------+
Control | 111 | 47 | 158
| 24.03 | 10.17 | 34.20
---------+--------+--------+
Total 338 124 462
73.16 26.84 100.00
Frequency Missing = 26
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 1.0334 0.3094
Likelihood Ratio Chi-Square 1 1.0232 0.3118
Continuity Adj. Chi-Square 1 0.8206 0.3650
Mantel-Haenszel Chi-Square 1 1.0312 0.3099
Phi Coefficient 0.0473
Contingency Coefficient 0.0472
Cramer's V 0.0473
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 227
Left-sided Pr <= F 0.8699
Right-sided Pr >= F 0.1822
Table Probability (P) 0.0522
Two-sided Pr <= P 0.3207
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.2483 0.8137 1.9150
Cohort (Col1 Risk) 1.0629 0.9420 1.1993
Cohort (Col2 Risk) 0.8515 0.6260 1.1583
Effective Sample Size = 462
Frequency Missing = 26
European-American Asthma 13:43 Monday, May 6, 2002 16
SNP = NOD2-004827
Allele Frequency
Frequency|
Percent |GG |GT |TT | Total
---------+--------+--------+--------+
Case | 87 | 53 | 12 | 152
| 37.66 | 22.94 | 5.19 | 65.80
---------+--------+--------+--------+
Control | 38 | 35 | 6 | 79
| 16.45 | 15.15 | 2.60 | 34.20
---------+--------+--------+--------+
Total 125 88 18 231
54.11 38.10 7.79 100.00
Frequency Missing = 13
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 2.0225 0.3638
Likelihood Ratio Chi-Square 2 2.0102 0.3660
Mantel-Haenszel Chi-Square 1 0.9990 0.3176
Phi Coefficient 0.0936
Contingency Coefficient 0.0932
Cramer's V 0.0936
Pearson Chi-Square Test
----------------------------------
Chi-Square 2.0225
DF 2
Asymptotic Pr > ChiSq 0.3638
Exact Pr >= ChiSq 0.3929
Effective Sample Size = 231
Frequency Missing = 13
European-American Asthma 13:43 Monday, May 6, 2002 17
SNP = NOD2-016077
Allele Frequency
Frequency|
Percent |C |T | Total
---------+--------+--------+
Case | 234 | 80 | 314
| 49.58 | 16.95 | 66.53
---------+--------+--------+
Control | 110 | 48 | 158
| 23.31 | 10.17 | 33.47
---------+--------+--------+
Total 344 128 472
72.88 27.12 100.00
Frequency Missing = 16
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 1.2780 0.2583
Likelihood Ratio Chi-Square 1 1.2637 0.2610
Continuity Adj. Chi-Square 1 1.0420 0.3074
Mantel-Haenszel Chi-Square 1 1.2752 0.2588
Phi Coefficient 0.0520
Contingency Coefficient 0.0520
Cramer's V 0.0520
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 234
Left-sided Pr <= F 0.8921
Right-sided Pr >= F 0.1537
Table Probability (P) 0.0458
Two-sided Pr <= P 0.2736
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.2764 0.8357 1.9495
Cohort (Col1 Risk) 1.0704 0.9478 1.2088
Cohort (Col2 Risk) 0.8386 0.6197 1.1349
Effective Sample Size = 472
Frequency Missing = 16
European-American Asthma 13:43 Monday, May 6, 2002 18
SNP = NOD2-016077
Allele Frequency
Frequency|
Percent |CC |CT |TT | Total
---------+--------+--------+--------+
Case | 90 | 54 | 13 | 157
| 38.14 | 22.88 | 5.51 | 66.53
---------+--------+--------+--------+
Control | 36 | 38 | 5 | 79
| 15.25 | 16.10 | 2.12 | 33.47
---------+--------+--------+--------+
Total 126 92 18 236
53.39 38.98 7.63 100.00
Frequency Missing = 8
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 4.1553 0.1252
Likelihood Ratio Chi-Square 2 4.1181 0.1276
Mantel-Haenszel Chi-Square 1 1.2552 0.2626
Phi Coefficient 0.1327
Contingency Coefficient 0.1315
Cramer's V 0.1327
Pearson Chi-Square Test
----------------------------------
Chi-Square 4.1553
DF 2
Asymptotic Pr > ChiSq 0.1252
Exact Pr >= ChiSq 0.1309
Effective Sample Size = 236
Frequency Missing = 8
European-American Asthma 13:43 Monday, May 6, 2002 19
SNP = NOD2-031000
Allele Frequency
Frequency|
Percent |A |T | Total
---------+--------+--------+
Case | 100 | 198 | 298
| 22.03 | 43.61 | 65.64
---------+--------+--------+
Control | 57 | 99 | 156
| 12.56 | 21.81 | 34.36
---------+--------+--------+
Total 157 297 454
34.58 65.42 100.00
Frequency Missing = 34
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.4023 0.5259
Likelihood Ratio Chi-Square 1 0.4007 0.5267
Continuity Adj. Chi-Square 1 0.2813 0.5958
Mantel-Haenszel Chi-Square 1 0.4014 0.5263
Phi Coefficient -0.0298
Contingency Coefficient 0.0298
Cramer's V -0.0298
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 100
Left-sided Pr <= F 0.2971
Right-sided Pr >= F 0.7702
Table Probability (P) 0.0674
Two-sided Pr <= P 0.5346
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 0.8772 0.5851 1.3152
Cohort (Col1 Risk) 0.9184 0.7072 1.1927
Cohort (Col2 Risk) 1.0470 0.9067 1.2089
Effective Sample Size = 454
Frequency Missing = 34
European-American Asthma 13:43 Monday, May 6, 2002 20
SNP = NOD2-031000
Allele Frequency
Frequency|
Percent |AA |TA |TT | Total
---------+--------+--------+--------+
Case | 19 | 62 | 68 | 149
| 8.37 | 27.31 | 29.96 | 65.64
---------+--------+--------+--------+
Control | 9 | 39 | 30 | 78
| 3.96 | 17.18 | 13.22 | 34.36
---------+--------+--------+--------+
Total 28 101 98 227
12.33 44.49 43.17 100.00
Frequency Missing = 17
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 1.4816 0.4767
Likelihood Ratio Chi-Square 2 1.4794 0.4773
Mantel-Haenszel Chi-Square 1 0.3940 0.5302
Phi Coefficient 0.0808
Contingency Coefficient 0.0805
Cramer's V 0.0808
Pearson Chi-Square Test
----------------------------------
Chi-Square 1.4816
DF 2
Asymptotic Pr > ChiSq 0.4767
Exact Pr >= ChiSq 0.4968
Effective Sample Size = 227
Frequency Missing = 17
European-American Asthma 13:43 Monday, May 6, 2002 21
SNP = NOD2-031184
Allele Frequency
Frequency|
Percent |A |T | Total
---------+--------+--------+
Case | 11 | 285 | 296
| 2.43 | 63.05 | 65.49
---------+--------+--------+
Control | 3 | 153 | 156
| 0.66 | 33.85 | 34.51
---------+--------+--------+
Total 14 438 452
3.10 96.90 100.00
Frequency Missing = 36
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 1.0944 0.2955
Likelihood Ratio Chi-Square 1 1.1817 0.2770
Continuity Adj. Chi-Square 1 0.5785 0.4469
Mantel-Haenszel Chi-Square 1 1.0920 0.2960
Phi Coefficient 0.0492
Contingency Coefficient 0.0491
Cramer's V 0.0492
WARNING: 25% of the cells have expected counts less
than 5. Chi-Square may not be a valid test.
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 11
Left-sided Pr <= F 0.9136
Right-sided Pr >= F 0.2279
Table Probability (P) 0.1416
Two-sided Pr <= P 0.3976
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.9684 0.5410 7.1625
Cohort (Col1 Risk) 1.9324 0.5472 6.8248
Cohort (Col2 Risk) 0.9817 0.9514 1.0130
Effective Sample Size = 452
Frequency Missing = 36
European-American Asthma 13:43 Monday, May 6, 2002 22
SNP = NOD2-031184
Allele Frequency
Frequency|
Percent |TA |TT | Total
---------+--------+--------+
Case | 11 | 137 | 148
| 4.87 | 60.62 | 65.49
---------+--------+--------+
Control | 3 | 75 | 78
| 1.33 | 33.19 | 34.51
---------+--------+--------+
Total 14 212 226
6.19 93.81 100.00
Frequency Missing = 18
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 1.1305 0.2877
Likelihood Ratio Chi-Square 1 1.2176 0.2698
Continuity Adj. Chi-Square 1 0.5976 0.4395
Mantel-Haenszel Chi-Square 1 1.1255 0.2887
Phi Coefficient 0.0707
Contingency Coefficient 0.0706
Cramer's V 0.0707
WARNING: 25% of the cells have expected counts less than 5.
(Asymptotic) Chi-Square may not be a valid test.
Pearson Chi-Square Test
----------------------------------
Chi-Square 1.1305
DF 1
Asymptotic Pr > ChiSq 0.2877
Exact Pr >= ChiSq 0.3897
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 11
Left-sided Pr <= F 0.9171
Right-sided Pr >= F 0.2238
Table Probability (P) 0.1409
Two-sided Pr <= P 0.3897
European-American Asthma 13:43 Monday, May 6, 2002 23
SNP = NOD2-031184
Statistics for Table of Allele Frequency
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 2.0073 0.5431 7.4192
Cohort (Col1 Risk) 1.9324 0.5554 6.7233
Cohort (Col2 Risk) 0.9627 0.9033 1.0260
Odds Ratio (Case-Control Study)
-----------------------------------
Odds Ratio 2.0073
Asymptotic Conf Limits
95% Lower Conf Limit 0.5431
95% Upper Conf Limit 7.4192
Exact Conf Limits
95% Lower Conf Limit 0.5074
95% Upper Conf Limit 11.5173
Effective Sample Size = 226
Frequency Missing = 18
European-American MI 13:43 Monday, May 6, 2002 24
SNP = NOD2-001681
Allele Frequency
Frequency|
Percent |A |G | Total
---------+--------+--------+
Case | 67 | 199 | 266
| 16.75 | 49.75 | 66.50
---------+--------+--------+
Control | 30 | 104 | 134
| 7.50 | 26.00 | 33.50
---------+--------+--------+
Total 97 303 400
24.25 75.75 100.00
Frequency Missing = 20
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.3803 0.5374
Likelihood Ratio Chi-Square 1 0.3838 0.5356
Continuity Adj. Chi-Square 1 0.2431 0.6219
Mantel-Haenszel Chi-Square 1 0.3793 0.5380
Phi Coefficient 0.0308
Contingency Coefficient 0.0308
Cramer's V 0.0308
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 67
Left-sided Pr <= F 0.7694
Right-sided Pr >= F 0.3130
Table Probability (P) 0.0823
Two-sided Pr <= P 0.6213
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.1672 0.7139 1.9082
Cohort (Col1 Risk) 1.1251 0.7715 1.6406
Cohort (Col2 Risk) 0.9639 0.8596 1.0810
Effective Sample Size = 400
Frequency Missing = 20
European-American MI 13:43 Monday, May 6, 2002 25
SNP = NOD2-001681
Allele Frequency
Frequency|
Percent |AA |GA |GG | Total
---------+--------+--------+--------+
Case | 11 | 45 | 77 | 133
| 5.50 | 22.50 | 38.50 | 66.50
---------+--------+--------+--------+
Control | 2 | 26 | 39 | 67
| 1.00 | 13.00 | 19.50 | 33.50
---------+--------+--------+--------+
Total 13 71 116 200
6.50 35.50 58.00 100.00
Frequency Missing = 10
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 2.2260 0.3286
Likelihood Ratio Chi-Square 2 2.4939 0.2874
Mantel-Haenszel Chi-Square 1 0.3661 0.5452
Phi Coefficient 0.1055
Contingency Coefficient 0.1049
Cramer's V 0.1055
Pearson Chi-Square Test
----------------------------------
Chi-Square 2.2260
DF 2
Asymptotic Pr > ChiSq 0.3286
Exact Pr >= ChiSq 0.3455
Effective Sample Size = 200
Frequency Missing = 10
European-American MI 13:43 Monday, May 6, 2002 26
SNP = NOD2-004827
Allele Frequency
Frequency|
Percent |G |T | Total
---------+--------+--------+
Case | 209 | 63 | 272
| 51.48 | 15.52 | 67.00
---------+--------+--------+
Control | 108 | 26 | 134
| 26.60 | 6.40 | 33.00
---------+--------+--------+
Total 317 89 406
78.08 21.92 100.00
Frequency Missing = 14
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.7410 0.3893
Likelihood Ratio Chi-Square 1 0.7524 0.3857
Continuity Adj. Chi-Square 1 0.5377 0.4634
Mantel-Haenszel Chi-Square 1 0.7392 0.3899
Phi Coefficient -0.0427
Contingency Coefficient 0.0427
Cramer's V -0.0427
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 209
Left-sided Pr <= F 0.2329
Right-sided Pr >= F 0.8385
Table Probability (P) 0.0714
Two-sided Pr <= P 0.4447
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 0.7986 0.4784 1.3333
Cohort (Col1 Risk) 0.9534 0.8578 1.0596
Cohort (Col2 Risk) 1.1937 0.7943 1.7940
Effective Sample Size = 406
Frequency Missing = 14
European-American MI 13:43 Monday, May 6, 2002 27
SNP = NOD2-004827
Allele Frequency
Frequency|
Percent |GG |GT |TT | Total
---------+--------+--------+--------+
Case | 82 | 45 | 9 | 136
| 40.39 | 22.17 | 4.43 | 67.00
---------+--------+--------+--------+
Control | 42 | 24 | 1 | 67
| 20.69 | 11.82 | 0.49 | 33.00
---------+--------+--------+--------+
Total 124 69 10 203
61.08 33.99 4.93 100.00
Frequency Missing = 7
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 2.5341 0.2817
Likelihood Ratio Chi-Square 2 3.0649 0.2160
Mantel-Haenszel Chi-Square 1 0.7322 0.3922
Phi Coefficient 0.1117
Contingency Coefficient 0.1110
Cramer's V 0.1117
Pearson Chi-Square Test
----------------------------------
Chi-Square 2.5341
DF 2
Asymptotic Pr > ChiSq 0.2817
Exact Pr >= ChiSq 0.3009
Effective Sample Size = 203
Frequency Missing = 7
European-American MI 13:43 Monday, May 6, 2002 28
SNP = NOD2-016077
Allele Frequency
Frequency|
Percent |C |T | Total
---------+--------+--------+
Case | 201 | 55 | 256
| 51.54 | 14.10 | 65.64
---------+--------+--------+
Control | 107 | 27 | 134
| 27.44 | 6.92 | 34.36
---------+--------+--------+
Total 308 82 390
78.97 21.03 100.00
Frequency Missing = 30
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.0944 0.7586
Likelihood Ratio Chi-Square 1 0.0949 0.7580
Continuity Adj. Chi-Square 1 0.0311 0.8599
Mantel-Haenszel Chi-Square 1 0.0942 0.7589
Phi Coefficient -0.0156
Contingency Coefficient 0.0156
Cramer's V -0.0156
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 201
Left-sided Pr <= F 0.4331
Right-sided Pr >= F 0.6669
Table Probability (P) 0.1000
Two-sided Pr <= P 0.7949
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 0.9222 0.5500 1.5462
Cohort (Col1 Risk) 0.9833 0.8840 1.0938
Cohort (Col2 Risk) 1.0663 0.7073 1.6073
Effective Sample Size = 390
Frequency Missing = 30
European-American MI 13:43 Monday, May 6, 2002 29
SNP = NOD2-016077
Allele Frequency
Frequency|
Percent |CC |CT |TT | Total
---------+--------+--------+--------+
Case | 80 | 41 | 7 | 128
| 41.03 | 21.03 | 3.59 | 65.64
---------+--------+--------+--------+
Control | 42 | 23 | 2 | 67
| 21.54 | 11.79 | 1.03 | 34.36
---------+--------+--------+--------+
Total 122 64 9 195
62.56 32.82 4.62 100.00
Frequency Missing = 15
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 0.6588 0.7194
Likelihood Ratio Chi-Square 2 0.7025 0.7038
Mantel-Haenszel Chi-Square 1 0.0929 0.7606
Phi Coefficient 0.0581
Contingency Coefficient 0.0580
Cramer's V 0.0581
Pearson Chi-Square Test
----------------------------------
Chi-Square 0.6588
DF 2
Asymptotic Pr > ChiSq 0.7194
Exact Pr >= ChiSq 0.7275
Effective Sample Size = 195
Frequency Missing = 15
European-American MI 13:43 Monday, May 6, 2002 30
SNP = NOD2-031000
Allele Frequency
Frequency|
Percent |A |T | Total
---------+--------+--------+
Case | 105 | 159 | 264
| 26.12 | 39.55 | 65.67
---------+--------+--------+
Control | 60 | 78 | 138
| 14.93 | 19.40 | 34.33
---------+--------+--------+
Total 165 237 402
41.04 58.96 100.00
Frequency Missing = 18
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.5143 0.4733
Likelihood Ratio Chi-Square 1 0.5130 0.4739
Continuity Adj. Chi-Square 1 0.3725 0.5416
Mantel-Haenszel Chi-Square 1 0.5130 0.4739
Phi Coefficient -0.0358
Contingency Coefficient 0.0357
Cramer's V -0.0358
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 105
Left-sided Pr <= F 0.2704
Right-sided Pr >= F 0.7952
Table Probability (P) 0.0656
Two-sided Pr <= P 0.5220
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 0.8585 0.5657 1.3029
Cohort (Col1 Risk) 0.9148 0.7187 1.1644
Cohort (Col2 Risk) 1.0656 0.8935 1.2708
Effective Sample Size = 402
Frequency Missing = 18
European-American MI 13:43 Monday, May 6, 2002 31
SNP = NOD2-031000
Allele Frequency
Frequency|
Percent |AA |TA |TT | Total
---------+--------+--------+--------+
Case | 21 | 63 | 48 | 132
| 10.45 | 31.34 | 23.88 | 65.67
---------+--------+--------+--------+
Control | 12 | 36 | 21 | 69
| 5.97 | 17.91 | 10.45 | 34.33
---------+--------+--------+--------+
Total 33 99 69 201
16.42 49.25 34.33 100.00
Frequency Missing = 9
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 0.7065 0.7024
Likelihood Ratio Chi-Square 2 0.7135 0.6999
Mantel-Haenszel Chi-Square 1 0.5209 0.4704
Phi Coefficient 0.0593
Contingency Coefficient 0.0592
Cramer's V 0.0593
Pearson Chi-Square Test
----------------------------------
Chi-Square 0.7065
DF 2
Asymptotic Pr > ChiSq 0.7024
Exact Pr >= ChiSq 0.7162
Effective Sample Size = 201
Frequency Missing = 9
European-American MI 13:43 Monday, May 6, 2002 32
SNP = NOD2-031184
Allele Frequency
Frequency|
Percent |A |T | Total
---------+--------+--------+
Case | 7 | 259 | 266
| 1.74 | 64.43 | 66.17
---------+--------+--------+
Control | 3 | 133 | 136
| 0.75 | 33.08 | 33.83
---------+--------+--------+
Total 10 392 402
2.49 97.51 100.00
Frequency Missing = 18
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.0672 0.7954
Likelihood Ratio Chi-Square 1 0.0685 0.7935
Continuity Adj. Chi-Square 1 0.0000 1.0000
Mantel-Haenszel Chi-Square 1 0.0671 0.7957
Phi Coefficient 0.0129
Contingency Coefficient 0.0129
Cramer's V 0.0129
WARNING: 25% of the cells have expected counts less
than 5. Chi-Square may not be a valid test.
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 7
Left-sided Pr <= F 0.7154
Right-sided Pr >= F 0.5455
Table Probability (P) 0.2609
Two-sided Pr <= P 1.0000
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.1982 0.3049 4.7086
Cohort (Col1 Risk) 1.1930 0.3134 4.5407
Cohort (Col2 Risk) 0.9956 0.9642 1.0281
Effective Sample Size = 402
Frequency Missing = 18
European-American MI 13:43 Monday, May 6, 2002 33
SNP = NOD2-031184
Allele Frequency
Frequency|
Percent |TA |TT | Total
---------+--------+--------+
Case | 7 | 126 | 133
| 3.48 | 62.69 | 66.17
---------+--------+--------+
Control | 3 | 65 | 68
| 1.49 | 32.34 | 33.83
---------+--------+--------+
Total 10 191 201
4.98 95.02 100.00
Frequency Missing = 9
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.0690 0.7928
Likelihood Ratio Chi-Square 1 0.0703 0.7909
Continuity Adj. Chi-Square 1 0.0000 1.0000
Mantel-Haenszel Chi-Square 1 0.0686 0.7933
Phi Coefficient 0.0185
Contingency Coefficient 0.0185
Cramer's V 0.0185
WARNING: 25% of the cells have expected counts less than 5.
(Asymptotic) Chi-Square may not be a valid test.
Pearson Chi-Square Test
----------------------------------
Chi-Square 0.0690
DF 1
Asymptotic Pr > ChiSq 0.7928
Exact Pr >= ChiSq 1.0000
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 7
Left-sided Pr <= F 0.7185
Right-sided Pr >= F 0.5454
Table Probability (P) 0.2639
Two-sided Pr <= P 1.0000
European-American MI 13:43 Monday, May 6, 2002 34
SNP = NOD2-031184
Statistics for Table of Allele Frequency
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.2037 0.3012 4.8097
Cohort (Col1 Risk) 1.1930 0.3185 4.4684
Cohort (Col2 Risk) 0.9911 0.9288 1.0575
Odds Ratio (Case-Control Study)
-----------------------------------
Odds Ratio 1.2037
Asymptotic Conf Limits
95% Lower Conf Limit 0.3012
95% Upper Conf Limit 4.8097
Exact Conf Limits
95% Lower Conf Limit 0.2637
95% Upper Conf Limit 7.4433
Effective Sample Size = 201
Frequency Missing = 9
European-American DVT 13:43 Monday, May 6, 2002 35
SNP = NOD2-001681
Allele Frequency
Frequency|
Percent |A |G | Total
---------+--------+--------+
Case | 38 | 100 | 138
| 13.77 | 36.23 | 50.00
---------+--------+--------+
Control | 36 | 102 | 138
| 13.04 | 36.96 | 50.00
---------+--------+--------+
Total 74 202 276
26.81 73.19 100.00
Frequency Missing = 4
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.0739 0.7858
Likelihood Ratio Chi-Square 1 0.0739 0.7858
Continuity Adj. Chi-Square 1 0.0185 0.8919
Mantel-Haenszel Chi-Square 1 0.0736 0.7862
Phi Coefficient 0.0164
Contingency Coefficient 0.0164
Cramer's V 0.0164
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 38
Left-sided Pr <= F 0.6582
Right-sided Pr >= F 0.4460
Table Probability (P) 0.1041
Two-sided Pr <= P 0.8920
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.0767 0.6320 1.8343
Cohort (Col1 Risk) 1.0556 0.7146 1.5591
Cohort (Col2 Risk) 0.9804 0.8499 1.1309
Effective Sample Size = 276
Frequency Missing = 4
European-American DVT 13:43 Monday, May 6, 2002 36
SNP = NOD2-001681
Allele Frequency
Frequency|
Percent |AA |GA |GG | Total
---------+--------+--------+--------+
Case | 4 | 30 | 35 | 69
| 2.90 | 21.74 | 25.36 | 50.00
---------+--------+--------+--------+
Control | 5 | 26 | 38 | 69
| 3.62 | 18.84 | 27.54 | 50.00
---------+--------+--------+--------+
Total 9 56 73 138
6.52 40.58 52.90 100.00
Frequency Missing = 2
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 0.5201 0.7710
Likelihood Ratio Chi-Square 2 0.5206 0.7708
Mantel-Haenszel Chi-Square 1 0.0759 0.7829
Phi Coefficient 0.0614
Contingency Coefficient 0.0613
Cramer's V 0.0614
WARNING: 33% of the cells have expected counts less than 5.
(Asymptotic) Chi-Square may not be a valid test.
Pearson Chi-Square Test
----------------------------------
Chi-Square 0.5201
DF 2
Asymptotic Pr > ChiSq 0.7710
Exact Pr >= ChiSq 0.7948
Effective Sample Size = 138
Frequency Missing = 2
European-American DVT 13:43 Monday, May 6, 2002 37
SNP = NOD2-004827
Allele Frequency
Frequency|
Percent |G |T | Total
---------+--------+--------+
Case | 100 | 38 | 138
| 35.97 | 13.67 | 49.64
---------+--------+--------+
Control | 103 | 37 | 140
| 37.05 | 13.31 | 50.36
---------+--------+--------+
Total 203 75 278
73.02 26.98 100.00
Frequency Missing = 2
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.0433 0.8352
Likelihood Ratio Chi-Square 1 0.0433 0.8352
Continuity Adj. Chi-Square 1 0.0053 0.9419
Mantel-Haenszel Chi-Square 1 0.0431 0.8355
Phi Coefficient -0.0125
Contingency Coefficient 0.0125
Cramer's V -0.0125
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 100
Left-sided Pr <= F 0.4709
Right-sided Pr >= F 0.6342
Table Probability (P) 0.1051
Two-sided Pr <= P 0.8928
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 0.9453 0.5566 1.6056
Cohort (Col1 Risk) 0.9849 0.8537 1.1363
Cohort (Col2 Risk) 1.0419 0.7077 1.5340
Effective Sample Size = 278
Frequency Missing = 2
European-American DVT 13:43 Monday, May 6, 2002 38
SNP = NOD2-004827
Allele Frequency
Frequency|
Percent |GG |GT |TT | Total
---------+--------+--------+--------+
Case | 36 | 28 | 5 | 69
| 25.90 | 20.14 | 3.60 | 49.64
---------+--------+--------+--------+
Control | 38 | 27 | 5 | 70
| 27.34 | 19.42 | 3.60 | 50.36
---------+--------+--------+--------+
Total 74 55 10 139
53.24 39.57 7.19 100.00
Frequency Missing = 1
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 0.0650 0.9680
Likelihood Ratio Chi-Square 2 0.0650 0.9680
Mantel-Haenszel Chi-Square 1 0.0432 0.8354
Phi Coefficient 0.0216
Contingency Coefficient 0.0216
Cramer's V 0.0216
Pearson Chi-Square Test
----------------------------------
Chi-Square 0.0650
DF 2
Asymptotic Pr > ChiSq 0.9680
Exact Pr >= ChiSq 0.9641
Effective Sample Size = 139
Frequency Missing = 1
European-American DVT 13:43 Monday, May 6, 2002 39
SNP = NOD2-016077
Allele Frequency
Frequency|
Percent |C |T | Total
---------+--------+--------+
Case | 103 | 35 | 138
| 37.32 | 12.68 | 50.00
---------+--------+--------+
Control | 104 | 34 | 138
| 37.68 | 12.32 | 50.00
---------+--------+--------+
Total 207 69 276
75.00 25.00 100.00
Frequency Missing = 4
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.0193 0.8894
Likelihood Ratio Chi-Square 1 0.0193 0.8894
Continuity Adj. Chi-Square 1 0.0000 1.0000
Mantel-Haenszel Chi-Square 1 0.0193 0.8896
Phi Coefficient -0.0084
Contingency Coefficient 0.0084
Cramer's V -0.0084
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 103
Left-sided Pr <= F 0.5000
Right-sided Pr >= F 0.6094
Table Probability (P) 0.1094
Two-sided Pr <= P 1.0000
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 0.9621 0.5579 1.6591
Cohort (Col1 Risk) 0.9904 0.8642 1.1349
Cohort (Col2 Risk) 1.0294 0.6840 1.5492
Effective Sample Size = 276
Frequency Missing = 4
European-American DVT 13:43 Monday, May 6, 2002 40
SNP = NOD2-016077
Allele Frequency
Frequency|
Percent |CC |CT |TT | Total
---------+--------+--------+--------+
Case | 37 | 29 | 3 | 69
| 26.81 | 21.01 | 2.17 | 50.00
---------+--------+--------+--------+
Control | 39 | 26 | 4 | 69
| 28.26 | 18.84 | 2.90 | 50.00
---------+--------+--------+--------+
Total 76 55 7 138
55.07 39.86 5.07 100.00
Frequency Missing = 2
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 0.3591 0.8356
Likelihood Ratio Chi-Square 2 0.3597 0.8354
Mantel-Haenszel Chi-Square 1 0.0205 0.8862
Phi Coefficient 0.0510
Contingency Coefficient 0.0509
Cramer's V 0.0510
WARNING: 33% of the cells have expected counts less than 5.
(Asymptotic) Chi-Square may not be a valid test.
Pearson Chi-Square Test
----------------------------------
Chi-Square 0.3591
DF 2
Asymptotic Pr > ChiSq 0.8356
Exact Pr >= ChiSq 0.8458
Effective Sample Size = 138
Frequency Missing = 2
European-American DVT 13:43 Monday, May 6, 2002 41
SNP = NOD2-031000
Allele Frequency
Frequency|
Percent |A |T | Total
---------+--------+--------+
Case | 46 | 90 | 136
| 16.79 | 32.85 | 49.64
---------+--------+--------+
Control | 41 | 97 | 138
| 14.96 | 35.40 | 50.36
---------+--------+--------+
Total 87 187 274
31.75 68.25 100.00
Frequency Missing = 6
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.5348 0.4646
Likelihood Ratio Chi-Square 1 0.5350 0.4645
Continuity Adj. Chi-Square 1 0.3618 0.5475
Mantel-Haenszel Chi-Square 1 0.5329 0.4654
Phi Coefficient 0.0442
Contingency Coefficient 0.0441
Cramer's V 0.0442
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 46
Left-sided Pr <= F 0.8054
Right-sided Pr >= F 0.2738
Table Probability (P) 0.0792
Two-sided Pr <= P 0.5170
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.2092 0.7266 2.0125
Cohort (Col1 Risk) 1.1385 0.8038 1.6124
Cohort (Col2 Risk) 0.9415 0.8008 1.1069
Effective Sample Size = 274
Frequency Missing = 6
European-American DVT 13:43 Monday, May 6, 2002 42
SNP = NOD2-031000
Allele Frequency
Frequency|
Percent |AA |TA |TT | Total
---------+--------+--------+--------+
Case | 8 | 30 | 30 | 68
| 5.84 | 21.90 | 21.90 | 49.64
---------+--------+--------+--------+
Control | 6 | 29 | 34 | 69
| 4.38 | 21.17 | 24.82 | 50.36
---------+--------+--------+--------+
Total 14 59 64 137
10.22 43.07 46.72 100.00
Frequency Missing = 3
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 0.5454 0.7613
Likelihood Ratio Chi-Square 2 0.5465 0.7609
Mantel-Haenszel Chi-Square 1 0.5276 0.4676
Phi Coefficient 0.0631
Contingency Coefficient 0.0630
Cramer's V 0.0631
Pearson Chi-Square Test
----------------------------------
Chi-Square 0.5454
DF 2
Asymptotic Pr > ChiSq 0.7613
Exact Pr >= ChiSq 0.7516
Effective Sample Size = 137
Frequency Missing = 3
European-American DVT 13:43 Monday, May 6, 2002 43
SNP = NOD2-031184
Allele Frequency
Frequency|
Percent |A |T | Total
---------+--------+--------+
Case | 3 | 131 | 134
| 1.10 | 48.16 | 49.26
---------+--------+--------+
Control | 6 | 132 | 138
| 2.21 | 48.53 | 50.74
---------+--------+--------+
Total 9 263 272
3.31 96.69 100.00
Frequency Missing = 8
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.9452 0.3309
Likelihood Ratio Chi-Square 1 0.9644 0.3261
Continuity Adj. Chi-Square 1 0.4009 0.5266
Mantel-Haenszel Chi-Square 1 0.9417 0.3318
Phi Coefficient -0.0589
Contingency Coefficient 0.0588
Cramer's V -0.0589
WARNING: 50% of the cells have expected counts less
than 5. Chi-Square may not be a valid test.
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 3
Left-sided Pr <= F 0.2650
Right-sided Pr >= F 0.9065
Table Probability (P) 0.1715
Two-sided Pr <= P 0.5009
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 0.5038 0.1234 2.0571
Cohort (Col1 Risk) 0.5149 0.1315 2.0170
Cohort (Col2 Risk) 1.0220 0.9782 1.0679
Effective Sample Size = 272
Frequency Missing = 8
European-American DVT 13:43 Monday, May 6, 2002 44
SNP = NOD2-031184
Allele Frequency
Frequency|
Percent |TA |TT | Total
---------+--------+--------+
Case | 3 | 64 | 67
| 2.21 | 47.06 | 49.26
---------+--------+--------+
Control | 6 | 63 | 69
| 4.41 | 46.32 | 50.74
---------+--------+--------+
Total 9 127 136
6.62 93.38 100.00
Frequency Missing = 4
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 0.9787 0.3225
Likelihood Ratio Chi-Square 1 0.9979 0.3178
Continuity Adj. Chi-Square 1 0.4151 0.5194
Mantel-Haenszel Chi-Square 1 0.9715 0.3243
Phi Coefficient -0.0848
Contingency Coefficient 0.0845
Cramer's V -0.0848
WARNING: 50% of the cells have expected counts less than 5.
(Asymptotic) Chi-Square may not be a valid test.
Pearson Chi-Square Test
----------------------------------
Chi-Square 0.9787
DF 1
Asymptotic Pr > ChiSq 0.3225
Exact Pr >= ChiSq 0.4932
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 3
Left-sided Pr <= F 0.2613
Right-sided Pr >= F 0.9103
Table Probability (P) 0.1716
Two-sided Pr <= P 0.4932
European-American DVT 13:43 Monday, May 6, 2002 45
SNP = NOD2-031184
Statistics for Table of Allele Frequency
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 0.4922 0.1179 2.0544
Cohort (Col1 Risk) 0.5149 0.1342 1.9754
Cohort (Col2 Risk) 1.0462 0.9567 1.1440
Odds Ratio (Case-Control Study)
-----------------------------------
Odds Ratio 0.4922
Asymptotic Conf Limits
95% Lower Conf Limit 0.1179
95% Upper Conf Limit 2.0544
Exact Conf Limits
95% Lower Conf Limit 0.0767
95% Upper Conf Limit 2.4373
Effective Sample Size = 136
Frequency Missing = 4
African-American Asthma 13:43 Monday, May 6, 2002 46
SNP = NOD2-001681
Allele Frequency
Frequency|
Percent |A |G | Total
---------+--------+--------+
Case | 11 | 133 | 144
| 3.27 | 39.58 | 42.86
---------+--------+--------+
Control | 31 | 161 | 192
| 9.23 | 47.92 | 57.14
---------+--------+--------+
Total 42 294 336
12.50 87.50 100.00
Frequency Missing = 28
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 5.4444 0.0196
Likelihood Ratio Chi-Square 1 5.7111 0.0169
Continuity Adj. Chi-Square 1 4.6944 0.0303
Mantel-Haenszel Chi-Square 1 5.4282 0.0198
Phi Coefficient -0.1273
Contingency Coefficient 0.1263
Cramer's V -0.1273
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 11
Left-sided Pr <= F 0.0138
Right-sided Pr >= F 0.9947
Table Probability (P) 0.0085
Two-sided Pr <= P 0.0202
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 0.4295 0.2080 0.8870
Cohort (Col1 Risk) 0.4731 0.2462 0.9090
Cohort (Col2 Risk) 1.1014 1.0190 1.1906
Effective Sample Size = 336
Frequency Missing = 28
African-American Asthma 13:43 Monday, May 6, 2002 47
SNP = NOD2-001681
Allele Frequency
Frequency|
Percent |AA |GA |GG | Total
---------+--------+--------+--------+
Case | 0 | 11 | 61 | 72
| 0.00 | 6.55 | 36.31 | 42.86
---------+--------+--------+--------+
Control | 4 | 23 | 69 | 96
| 2.38 | 13.69 | 41.07 | 57.14
---------+--------+--------+--------+
Total 4 34 130 168
2.38 20.24 77.38 100.00
Frequency Missing = 14
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 5.4094 0.0669
Likelihood Ratio Chi-Square 2 6.9254 0.0313
Mantel-Haenszel Chi-Square 1 5.0352 0.0248
Phi Coefficient 0.1794
Contingency Coefficient 0.1766
Cramer's V 0.1794
WARNING: 33% of the cells have expected counts less than 5.
(Asymptotic) Chi-Square may not be a valid test.
Pearson Chi-Square Test
----------------------------------
Chi-Square 5.4094
DF 2
Asymptotic Pr > ChiSq 0.0669
Exact Pr >= ChiSq 0.0764
Effective Sample Size = 168
Frequency Missing = 14
African-American Asthma 13:43 Monday, May 6, 2002 48
SNP = NOD2-004827
Allele Frequency
Frequency|
Percent |G |T | Total
---------+--------+--------+
Case | 139 | 15 | 154
| 41.12 | 4.44 | 45.56
---------+--------+--------+
Control | 156 | 28 | 184
| 46.15 | 8.28 | 54.44
---------+--------+--------+
Total 295 43 338
87.28 12.72 100.00
Frequency Missing = 26
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 2.2650 0.1323
Likelihood Ratio Chi-Square 1 2.3064 0.1288
Continuity Adj. Chi-Square 1 1.7986 0.1799
Mantel-Haenszel Chi-Square 1 2.2583 0.1329
Phi Coefficient 0.0819
Contingency Coefficient 0.0816
Cramer's V 0.0819
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 139
Left-sided Pr <= F 0.9535
Right-sided Pr >= F 0.0892
Table Probability (P) 0.0427
Two-sided Pr <= P 0.1433
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 1.6632 0.8532 3.2423
Cohort (Col1 Risk) 1.0646 0.9825 1.1536
Cohort (Col2 Risk) 0.6401 0.3550 1.1541
Effective Sample Size = 338
Frequency Missing = 26
African-American Asthma 13:43 Monday, May 6, 2002 49
SNP = NOD2-004827
Allele Frequency
Frequency|
Percent |GG |GT |TT | Total
---------+--------+--------+--------+
Case | 63 | 13 | 1 | 77
| 37.28 | 7.69 | 0.59 | 45.56
---------+--------+--------+--------+
Control | 68 | 20 | 4 | 92
| 40.24 | 11.83 | 2.37 | 54.44
---------+--------+--------+--------+
Total 131 33 5 169
77.51 19.53 2.96 100.00
Frequency Missing = 13
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 2.1614 0.3394
Likelihood Ratio Chi-Square 2 2.2814 0.3196
Mantel-Haenszel Chi-Square 1 2.0091 0.1564
Phi Coefficient 0.1131
Contingency Coefficient 0.1124
Cramer's V 0.1131
WARNING: 33% of the cells have expected counts less than 5.
(Asymptotic) Chi-Square may not be a valid test.
Pearson Chi-Square Test
----------------------------------
Chi-Square 2.1614
DF 2
Asymptotic Pr > ChiSq 0.3394
Exact Pr >= ChiSq 0.3718
Effective Sample Size = 169
Frequency Missing = 13
African-American Asthma 13:43 Monday, May 6, 2002 50
SNP = NOD2-016077
Allele Frequency
Frequency|
Percent |C |T | Total
---------+--------+--------+
Case | 136 | 8 | 144
| 40.48 | 2.38 | 42.86
---------+--------+--------+
Control | 161 | 31 | 192
| 47.92 | 9.23 | 57.14
---------+--------+--------+
Total 297 39 336
88.39 11.61 100.00
Frequency Missing = 28
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 8.9949 0.0027
Likelihood Ratio Chi-Square 1 9.7122 0.0018
Continuity Adj. Chi-Square 1 7.9923 0.0047
Mantel-Haenszel Chi-Square 1 8.9681 0.0027
Phi Coefficient 0.1636
Contingency Coefficient 0.1615
Cramer's V 0.1636
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 136
Left-sided Pr <= F 0.9995
Right-sided Pr >= F 0.0018
Table Probability (P) 0.0013
Two-sided Pr <= P 0.0031
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 3.2733 1.4561 7.3585
Cohort (Col1 Risk) 1.1263 1.0463 1.2124
Cohort (Col2 Risk) 0.3441 0.1631 0.7260
Effective Sample Size = 336
Frequency Missing = 28
African-American Asthma 13:43 Monday, May 6, 2002 51
SNP = NOD2-016077
Allele Frequency
Frequency|
Percent |CC |CT |TT | Total
---------+--------+--------+--------+
Case | 64 | 8 | 0 | 72
| 38.10 | 4.76 | 0.00 | 42.86
---------+--------+--------+--------+
Control | 70 | 21 | 5 | 96
| 41.67 | 12.50 | 2.98 | 57.14
---------+--------+--------+--------+
Total 134 29 5 168
79.76 17.26 2.98 100.00
Frequency Missing = 14
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 7.8274 0.0200
Likelihood Ratio Chi-Square 2 9.8003 0.0074
Mantel-Haenszel Chi-Square 1 7.7163 0.0055
Phi Coefficient 0.2159
Contingency Coefficient 0.2110
Cramer's V 0.2159
WARNING: 33% of the cells have expected counts less than 5.
(Asymptotic) Chi-Square may not be a valid test.
Pearson Chi-Square Test
----------------------------------
Chi-Square 7.8274
DF 2
Asymptotic Pr > ChiSq 0.0200
Exact Pr >= ChiSq 0.0154
Effective Sample Size = 168
Frequency Missing = 14
African-American Asthma 13:43 Monday, May 6, 2002 52
SNP = NOD2-031000
Allele Frequency
Frequency|
Percent |A |T | Total
---------+--------+--------+
Case | 124 | 36 | 160
| 35.63 | 10.34 | 45.98
---------+--------+--------+
Control | 110 | 78 | 188
| 31.61 | 22.41 | 54.02
---------+--------+--------+
Total 234 114 348
67.24 32.76 100.00
Frequency Missing = 16
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 14.1500 0.0002
Likelihood Ratio Chi-Square 1 14.4270 0.0001
Continuity Adj. Chi-Square 1 13.3011 0.0003
Mantel-Haenszel Chi-Square 1 14.1094 0.0002
Phi Coefficient 0.2016
Contingency Coefficient 0.1977
Cramer's V 0.2016
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 124
Left-sided Pr <= F 1.0000
Right-sided Pr >= F 1.174E-04
Table Probability (P) 7.188E-05
Two-sided Pr <= P 2.293E-04
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Case-Control (Odds Ratio) 2.4424 1.5250 3.9118
Cohort (Col1 Risk) 1.3245 1.1441 1.5335
Cohort (Col2 Risk) 0.5423 0.3883 0.7573
Effective Sample Size = 348
Frequency Missing = 16
African-American Asthma 13:43 Monday, May 6, 2002 53
SNP = NOD2-031000
Allele Frequency
Frequency|
Percent |AA |TA |TT | Total
---------+--------+--------+--------+
Case | 47 | 30 | 3 | 80
| 27.01 | 17.24 | 1.72 | 45.98
---------+--------+--------+--------+
Control | 34 | 42 | 18 | 94
| 19.54 | 24.14 | 10.34 | 54.02
---------+--------+--------+--------+
Total 81 72 21 174
46.55 41.38 12.07 100.00
Frequency Missing = 8
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 2 13.7634 0.0010
Likelihood Ratio Chi-Square 2 14.8645 0.0006
Mantel-Haenszel Chi-Square 1 13.2632 0.0003
Phi Coefficient 0.2812
Contingency Coefficient 0.2707
Cramer's V 0.2812
Pearson Chi-Square Test
----------------------------------
Chi-Square 13.7634
DF 2
Asymptotic Pr > ChiSq 0.0010
Exact Pr >= ChiSq 9.559E-04
Effective Sample Size = 174
Frequency Missing = 8
African-American Asthma 13:43 Monday, May 6, 2002 54
SNP = NOD2-031184
Allele Frequency
Frequency|
Percent |A |T | Total
---------+--------+--------+
Case | 0 | 158 | 158
| 0.00 | 47.31 | 47.31
---------+--------+--------+
Control | 2 | 174 | 176
| 0.60 | 52.10 | 52.69
---------+--------+--------+
Total 2 332 334
0.60 99.40 100.00
Frequency Missing = 30
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 1.8063 0.1790
Likelihood Ratio Chi-Square 1 2.5734 0.1087
Continuity Adj. Chi-Square 1 0.4016 0.5263
Mantel-Haenszel Chi-Square 1 1.8009 0.1796
Phi Coefficient -0.0735
Contingency Coefficient 0.0733
Cramer's V -0.0735
WARNING: 50% of the cells have expected counts less
than 5. Chi-Square may not be a valid test.
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 0
Left-sided Pr <= F 0.2769
Right-sided Pr >= F 1.0000
Table Probability (P) 0.2769
Two-sided Pr <= P 0.5000
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Cohort (Col2 Risk) 1.0115 0.9956 1.0276
One or more risk estimates not computed --- zero cell.
Effective Sample Size = 334
Frequency Missing = 30
African-American Asthma 13:43 Monday, May 6, 2002 55
SNP = NOD2-031184
Allele Frequency
Frequency|
Percent |TA |TT | Total
---------+--------+--------+
Case | 0 | 79 | 79
| 0.00 | 47.31 | 47.31
---------+--------+--------+
Control | 2 | 86 | 88
| 1.20 | 51.50 | 52.69
---------+--------+--------+
Total 2 165 167
1.20 98.80 100.00
Frequency Missing = 15
Statistics for Table of Allele Frequency
Statistic DF Value Prob
------------------------------------------------------
Chi-Square 1 1.8172 0.1776
Likelihood Ratio Chi-Square 1 2.5844 0.1079
Continuity Adj. Chi-Square 1 0.4040 0.5250
Mantel-Haenszel Chi-Square 1 1.8063 0.1789
Phi Coefficient -0.1043
Contingency Coefficient 0.1038
Cramer's V -0.1043
WARNING: 50% of the cells have expected counts less than 5.
(Asymptotic) Chi-Square may not be a valid test.
Pearson Chi-Square Test
----------------------------------
Chi-Square 1.8172
DF 1
Asymptotic Pr > ChiSq 0.1776
Exact Pr >= ChiSq 0.4984
Fisher's Exact Test
----------------------------------
Cell (1,1) Frequency (F) 0
Left-sided Pr <= F 0.2762
Right-sided Pr >= F 1.0000
Table Probability (P) 0.2762
Two-sided Pr <= P 0.4984
Estimates of the Relative Risk (Row1/Row2)
Type of Study Value 95% Confidence Limits
-----------------------------------------------------------------
Cohort (Col2 Risk) 1.0233 0.9912 1.0564
One or more risk estimates not computed --- zero cell.
Effective Sample Size = 167
Frequency Missing = 15
|
