Innate Discrimination between Self and Non-self is Perfect
The effect of immune recognition is destruction of the target’
The structures selected for immune recognition must have been absolutely distinct from self antigens to avoid damage to self cells and tissues.
The ability of the innate immune system to discriminate between self and nonself is perfect.
None of the compounds recognized by the innate immune system are produced by the host organism, and all of them are essential for the physiology and survival of the respective microbes.